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Archives 2023
Myanmar Health Sciences Research Journal
Volume 35, Number 1-3
TITLE: Assessment of Safety and Immunogenicity of BBIBP-CorV (Myancopharm) COVID-19 Vaccine as a Third Dose (Booster) among Workers of Pharmaceutical Factory (Insein) in Yangon, Myanmar
AUTHOR: Mo Mo Win1#, Aung Kyaw Kyaw1#, Han Win1*, Thae Mg Mg1, Kyaw Lwin Show1, Wah Wah Aung1, Mu Mu Shwe1 Hlaing Myat Thu1 and Zaw Than Htun1
SOURCE: Myanmar Health Sciences Research Journal, 2023; 35(1-3): 1-9
ABSTRACT:
Vaccination is an important strategy to stop the
pandemic situation of COVID-19 infection. This study was
conducted to determine the
safety and immunogenicity of BBIBP-CorV (Myancopharm) as a third dose (booster)
among factory workers in Yangon. A single group prospective cohort study was
conducted in Pharmaceutical Factory (Insein), Yangon, 2022. A total of 306
workers who had received two doses of any kind of COVID-19 vaccine before 6
months of the screening were enrolled. Adverse Events (AEs) were assessed and
recorded by phone interviewing using Kobo Collect software. Safety
hematological and biochemical parameters were also assessed. Immunogenicity was
assessed by antibody (Ab) to SARS-CoV-2 spike antigen by Enzyme Linked
Fluorescent Assay (VIDAS® SARS-COV-2 IgG assay, Biomerieux, France). Among
306 participants, the mean age was 45.8±8.1 years and male to female ratio was
1:2.73. During the seven days after
vaccination, solicited local and systematic AEs were reported by 46(47.7%) and
97(31.7%) participants, respectively.
SUBJECT HEADINGS: Safety, Immunogenicity, BBIBP-CorV (Myancopharm), COVID-19 vaccine, Booster dose, Myanmar
FULL TEXT:

Vaccination is an important strategy to stop the pandemic situation of COVID-19 infection. This study was conducted to determine the
safety and immunogenicity of BBIBP-CorV (Myancopharm) as a third dose (booster) among factory workers in Yangon. A single group prospective cohort study was conducted in Pharmaceutical Factory (Insein), Yangon, 2022. A total of 306 workers who had received two doses of any kind of COVID-19 vaccine before 6 months of the screening were enrolled. Adverse Events (AEs) were assessed and recorded by phone interviewing using Kobo Collect software. Safety hematological and biochemical parameters were also assessed. Immunogenicity was assessed by antibody (Ab) to SARS-CoV-2 spike antigen by Enzyme Linked Fluorescent Assay (VIDAS® SARS-COV-2 IgG assay, Biomerieux, France). Among 306 participants, the mean age was 45.8±8.1 years and male to female ratio was 1:2.73. During the seven days after vaccination, solicited local and systematic AEs were reported by 46(47.7%) and 97(31.7%) participants, respectively.