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Archives 2021
Myanmar Health Sciences Research Journal
Volume 33, Number 1
TITLE: Molecular Detection of Epstein-Barr Virus (EBV) in Patients with Non-Hodgkin Lymphoma Attending the Haematology Units of Tertiary Care Hospitals in Yangon
AUTHOR: Moh Moh Htun, Tun Lwin Nyein, Aye Aye Gyi, Sein Win, Mya Ohnmar, Theingi Thet Paing Htun, Hnin Nu Htwe, Khin Kant Kaw Oo & Khine Moe Aung
SOURCE: Myanmar Health Sciences Research Journal
ABSTRACT:
Non-Hodgkin
Lymphoma (NHL) is one of the lymphoproliferative disorders and it is common
haematological malignancy in Myanmar.
A cross-sectional descriptive study involved 83 cases of Non-Hodgkin Lymphoma
(NHL) attending the Haematological Units, Yangon General Hospital and North
Okkalapa General and Teaching Hospital, Yangon from August 07 to September 08.
The mean age of NHL cases was 50.5±7.07
years and 47(57%) cases were male and 36(43%) cases were female. Out of 83 cases of NHL, 34(4%) cases were type
I indolent chronic lymphoma, 48(58%) cases were type II aggressive lymphoma and (%) case in type III
highly aggressive lymphoma. After extraction of DNA, EBNA was only detected in 6/83(9.3%) cases of NHL
at 6 base pair by using polymerase chain reaction (PCR). EBNA (300 base pair) was not found in all cases by using specific EBNA primer. EBV
serotype was found in 44% in Histological
Type I NHL, 50% in Type II NHL and 6% in Type III NHL, respectively. Type I NHL
was mostly in follicular lymphoma, small lymphocytic and extranodal histology
types and Type II NHL was mainly in diffuse large B cell lymphoma and anaplastic
large cell and Type III was mostly in plasmablastic B cell lymphoma. EBV-DNA was detected in low grade and
intermediate grade of NHL in this study.
SUBJECT HEADINGS: Non-Hodgkin lymphoma (NHL), Epstein-Barr virus (EBV), Polymerase Chain Reaction (PCR)
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