Myanmar Health Sciences Research Journal
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Aims of MHSR Journal
  • To serve as an important medium for the publication of original research in the field of medical science and health research, thus filling gaps in health knowledge for effective utilization of research findings
  • To impart current medical knowledge and updated scientific information obtained from research to health professionals for better and appropriate health care management
  • To disseminate recent basic, applied and social research findings among health personnel of different strata for enhancing worldwide health development


Archives   2021

Myanmar   Health   Sciences   Research   Journal

Volume   33,  Number   1

TITLE:   Molecular Detection of Epstein-Barr Virus (EBV) in Patients with Non-Hodgkin Lymphoma Attending the Haematology Units of Tertiary Care Hospitals in Yangon
AUTHOR:   Moh Moh Htun, Tun Lwin Nyein, Aye Aye Gyi, Sein Win, Mya Ohnmar, Theingi Thet Paing Htun, Hnin Nu Htwe, Khin Kant Kaw Oo & Khine Moe Aung
SOURCE:   Myanmar Health Sciences Research Journal
ABSTRACT:  

Non-Hodgkin Lymphoma (NHL) is one of the lymphoproliferative disorders and it is common haematological malignancy in Myanmar.
A cross-sectional descriptive study involved 83 cases of Non-Hodgkin Lymphoma (NHL) attending the Haematological Units, Yangon General Hospital and North Okkalapa General and Teaching Hospital, Yangon from August 07 to September 08. The mean age of NHL cases was 50.5±7.07 years and 47(57%) cases were male and 36(43%) cases were female. Out of 83 cases of NHL, 34(4%) cases were type I
indolent chronic lymphoma, 48(58%) cases were type II aggressive lymphoma and (%) case in type III highly aggressive lymphoma. After extraction of DNA, EBNA  was only detected in 6/83(9.3%) cases of NHL at 6 base pair by using polymerase chain reaction (PCR). EBNA (300 base pair) was not found in all cases by using specific EBNA primer. EBV serotype  was found in 44% in Histological Type I NHL, 50% in Type II NHL and 6% in Type III NHL, respectively. Type I NHL was mostly in follicular lymphoma, small lymphocytic and extranodal histology types and Type II NHL was mainly in diffuse large B cell lymphoma and anaplastic large cell and Type III was mostly in plasmablastic B cell lymphoma. EBV-DNA was detected in low grade and intermediate grade of NHL in this study. 


SUBJECT HEADINGS:   Non-Hodgkin lymphoma (NHL), Epstein-Barr virus (EBV), Polymerase Chain Reaction (PCR)
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Vision : Achieving a healthier nation through application of research findings          Mission Statement : To Develop and promote solutions to the major health problems of Myanmar