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Archives 2020
Myanmar Health Sciences Research Journal
Volume 32, Number 2
TITLE: Viral Pathogens Associated with Acute Lower Respiratory Infections Among Hospitalized Children in Yangon Children’s Hospital
AUTHOR: Han Win, Htin Lin, Mo Mo Win, Lay-Myint Yoshida, Wah Wah Aung, Hlaing Myat Thu & Ye Myint Kyaw
SOURCE: Myanmar Health Sciences Research Journal, 2020; 32(2): 180-184
ABSTRACT:
Viruses are common causes of lower respiratory tract disease in infants and young children and represent a major public health problem in children. The present study aimed to identify viral etiological agents of acute lower respiratory infections (ALRI) among children admitted to Yangon Children’s Hospital from February 2014 to August 2015. Clinical data and nasopharyngeal swab (NP) samples were collected. Four multiplex polymerase chain reaction assays were performed to detect 13 respiratory viruses in each NP sample. A total of 390 were enrolled. The age of the children ranged from one to 108 months with median age of 12 months. Of all study children, 202(51.8%) were non-severe ALRI and 188(48.2%) were severe ALRI cases. Presence of wheeze (p=0.001), attendance at kindergarten (p=0.01) and higher total WBC counts(p=0.004) were significantly associated with severe ALRI. Among 390 samples, 157(40.3%) were positive for at least one respiratory virus. Major viruses detected were rhinovirus (72, 18.5%), respiratory syncytial virus (30, 7.7%), adenovirus (17, 4.4%) and parainfluenza virus 3 (17, 4.4%). Respiratory syncytial virus(OR=1.35, 95% CI=1-1.8) and influenza A virus (OR=1.63, 95% CI=1.2-2.24) were associated with diagnosis of severe ALRI, but adenovirus (OR=0.35, 95% CI=0.13-0.99) was found to be related to less risk of severe ALRI. This study showed that rhinovirus, respiratory syncytial virus, adenovirus and parainfluenza virus 3 were leading cause of ALRI in hospitalized children and suggested that respiratory syncytial virus and influenza A virus may increase the severity of ALRI.
SUBJECT HEADINGS: Viral pathogens, Lower respiratory infections, Yangon Children’s Hospital
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