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Is Community Intervention Effective for Improving Maternal, Newborn and Child Health Care in Hard-to-Reach Areas of Chin State, Myanmar?

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Incidence of Snakebite in Four Townships of Yangon Region

The true incidence of snakebite in Myanmar is unknown. The current data are based on hospital returns to Ministry of Health and Sports and they are likely to be under-reported. A community-based survey is useful to know the current burden of snakebite and thus for planning and formulating str

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Aims of MHSR Journal

• To serve as an important medium for the publication of original research in the field of medical science and health research, thus filling gaps in health knowledge for effective utilization of research findings
• To impart current medical knowledge and updated scientific information obtained from research to health professionals for better and appropriate health care management
• To disseminate recent basic, applied and social research findings among health personnel of different strata for enhancing worldwide health development

Archives   2020

Myanmar   Health   Sciences   Research   Journal

Volume   32,  Number   2

TITLE:   Acute Toxicity of Three Medicinal Plants Using as Antidote in Myanmar
AUTHOR:   Swe Zin Aung, Khin May Thi, Ei Ei Htway, Aye Min Maw, Moh Moh Lwin, Aye Thida Htun, Zin Nwe Soe, Rai Kit, Khin Saw Aye
SOURCE:   Myanmar Health Sciences Research Journal, 2020; 32(2): 139-145
ABSTRACT:  

Snake bite and scorpion sting are the important causes of morbidity (life-threatening) and mortality for human being of rural area. In Myanmar, more than 8000 cases are reported and an estimated mortality rate was 750 to 1000 die annually each year. Regarding snake bite registry, Mandalay Region was more than Ayeyarwady (1203 vs. 122). In Myanmar Traditional Medicine and international literature, Stachytar-phetaindica (L.)Vahl(အဆိပ်တစ်ရာ), Mimosa pudica L. (ထိကရုန်း)and Amaranthusspinosus L. (ဟင်းနုနယ်ဆူးပေါက်) have been commonly used as antidotes for snake, scorpion, insect stinging evenomation and in other diseases as well. The present study, conducted from September 2017 to September 2018, was aimed to determine the acute toxicity of these three medicinal plants. Different extracts of aerial part of Stachytarpheta indica (L.) Vahl, the whole plant of Mimosa pudica L. and root of Amaranthus spinosus L. were prepared by Soxhlet extraction method with ethanol (95%). Acute oral toxicity testing on rats was performed by the main test according to OECD 425 guideline (2008). In phytochemical screening, allthree plants showed the presence of alkaloids, tannins, phenolic compounds, steroids, carbohydrates, glycosides and saponin. Protein and cyanogenic glycoside were not detected. The phytochemical compounds, flavonoids, starchs and cardiac glycosides were detected only Mimosa pudica L. and Stachytarpheta indica (L.) Vahl. From acute toxicity study, a single 5000 mg/kg dose of ethanol extracts did not show any lethal effect on the tested animals. The LD50 of the three plants were more than 5000 mg/kg Therefore, the present study proved that these three medicinal plants had not acute toxic effects. This study can give evidence for no toxic data for the three plants in community.