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Archives 2020
Myanmar Health Sciences Research Journal
Volume 32, Number 1
TITLE: Formulation of Capsule Dosage Form Containing Ethanolic Fruit Extract of Terminalia chebula Retz. (Hpan-ga) Having Potent Antioxidant Activity
AUTHOR: Wai Wai Lwin, Cho Yi Myint, Maung Maung & Khin Tar Yar Myint
SOURCE: Myanmar Health Sciences Research Journal, 2020; 32(1):66-72
ABSTRACT:
Recently, the usefulness of medicinal plants in health care delivery has been emphasized and WHO recognizes and endorses the use of those which have been scientifically proven to be efficacious, safe for use and of good quality. Thus, it is necessary to formulate these valuable herbal medicinal plants into dosage form. This study is aimed to formulate the capsule dosage form containing 75% ethanolic fruit extract of Terminalia chebula Retz. (Hpan-ga) having antioxidant activity. Prior to formulation into capsule dosage form, physicochemical and phytochemical characterization were investigated and all were complied with the specified limits prescribed in the Pharmacopoeias. In addition, according to the Folin-Ciocalteu colorimetric method, the total polyphenol content of 75% ethanolic extract was 270.664 mg GAE/g and IC50 value obtained from DPPH radical scavenging test was 0.238 mg/mL. Thus, ethanolic extract having antioxidant activity was formulated into capsule dosage form using four different formulations containing adsorbent-loaded dried extract. The pharmaceutical evaluation studies revealed that among different formulations, microcrystalline cellulose (MCC)-loaded dried extract capsule containing 3% talc showed short disintegration time (p<0.05), good uniformity of weight and dissolution. Thus, according to the study, capsule containing MCC-loaded dried extract granules with considerable amount of total polyphenol content showed reproducible capsule dosage form having antioxidant activity.
SUBJECT HEADINGS: Total polyphenol content, Antioxidant, DPPH, Capsule dosage form, MCC, Starch
FULL TEXT:
Recently, the usefulness of medicinal plants in health care delivery has been emphasized and WHO recognizes and endorses the use of those which have been scientifically proven to be efficacious, safe for use and of good quality. Thus, it is necessary to formulate these valuable herbal medicinal plants into dosage form. This study is aimed to formulate the capsule dosage form containing 75% ethanolic fruit extract of Terminalia chebula Retz. (Hpan-ga) having antioxidant activity. Prior to formulation into capsule dosage form, physicochemical and phytochemical characterization were investigated and all were complied with the specified limits prescribed in the Pharmacopoeias. In addition, according to the Folin-Ciocalteu colorimetric method, the total polyphenol content of 75% ethanolic extract was 270.664 mg GAE/g and IC50 value obtained from DPPH radical scavenging test was 0.238 mg/mL. Thus, ethanolic extract having antioxidant activity was formulated into capsule dosage form using four different formulations containing adsorbent-loaded dried extract. The pharmaceutical evaluation studies revealed that among different formulations, microcrystalline cellulose (MCC)-loaded dried extract capsule containing 3% talc showed short disintegration time (p<0.05), good uniformity of weight and dissolution. Thus, according to the study, capsule containing MCC-loaded dried extract granules with considerable amount of total polyphenol content showed reproducible capsule dosage form having antioxidant activity.