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Archives 2020
Myanmar Health Sciences Research Journal
Volume 32, Number 1
TITLE: Prevalence of Diabetes Mellitus in Subjects with Chronic Hepatitis C Infectio
AUTHOR: Swe Zin Oo, Aye Aye Win, Baby Hla, Hla Win Aung, Swe Zin Soe, May Mon Win Maw, Thandar Aung, Mya Ohnmar, & Win Naing
SOURCE: Myanmar Health Sciences Research Journal, 2020; 32(1):32-38
ABSTRACT:
Hepatitis C virus (HCV) infection and type 2 diabetes mellitus (T2DM) are two major public health problems associated with increasing complications and mortality rates worldwide. HCV infection and T2DM may coexist in an individual. HCV infected individuals have a greater chance of developing insulin resistance (IR) and diabetes (DM). Moreover, HCV patients with IR, with or without diabetes, have a poor response to antiviral treatment, increased progression of liver fibrosis and greater risk of developing hepatocellular carcinoma. Objectives of this study were to find out the estimated prevalence of diabetes mellitus in subjects with chronic hepatitis C infection and to find out the association between chronic HCV infection with other related features of diabetes such as age, gender, family history of diabetes and body mass index. A cross-sectional descriptive study was done in total 130 HCV- positive subjects from December 2016 to June 2017. Plasma glucose test, HbA1c test and liver function test were done. In this study, males were 56 (43.1%) and females were 74 (56.9%). Out of 130 subjects, 5 subjects (3.8%) were diagnosed as DM, where 63 subjects (48.5%) and 62 subjects (47.7%) were diagnosed as pre-diabetes and normal blood glucose level, respectively. In this study, the prevalence of DM case was low and the prevalence of pre-DM was relatively higher. In conclusion, early diagnosis of DM in HCV-positive subjects can give early treatment and better management of DM. Well control glycemic status in HCV-positive subjects will give slow progression of liver fibrosis and better response of antiviral treatment. This study also provided the awareness of pre-DM and early prevention of DM in pre-DM subjects by changing the healthy life styles.
SUBJECT HEADINGS: Chronic hepatitis C infection, Diabetes mellitus, Pre-diabetes, Insulin resistance
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