Myanmar Health Sciences Research Journal
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Aims of MHSR Journal
  • To serve as an important medium for the publication of original research in the field of medical science and health research, thus filling gaps in health knowledge for effective utilization of research findings
  • To impart current medical knowledge and updated scientific information obtained from research to health professionals for better and appropriate health care management
  • To disseminate recent basic, applied and social research findings among health personnel of different strata for enhancing worldwide health development


Archives   2020

Myanmar   Health   Sciences   Research   Journal

Volume   32,  Number   1

TITLE:   Serodetection of Hepatitis C Virus Infection among HIV Patients in Mingalardon Specialist Hospital
AUTHOR:   Tin Sandar Win, San Yu Maw, Yi Yi Kyaw & Win Win Maw
SOURCE:   Myanmar Health Sciences Research Journal, 2020; 32(1):19-24
ABSTRACT:  



Coinfection with hepatitis C virus in HIV-infected individuals results in increased hepatic complications. In the era of antiretroviral therapy, liver-related death among HIV patients is the most prevalent non-AIDS related cause. HIV and HCV share common pathways of mode of transmission. The aim of this study was to detect hepatitis C in HIV patients and to find out the coinfection rate in HIV patients from Mingalardon Specialist Hospital. The study was done at Molecular Technology Applications Division at Department of Medical Research from January 2016 to December 2016. A total of 150 participants including 83 males and 67 females were studied. Blood samples were tested for anti-HCV by enzyme-linked immunosorbent assay (ELISA) method. Anti-HCV was positive in 15 (9 males, 6 females) and the prevalence rate was found to be 10%. Anti-HCV positivity was found (33.3%, 5/15 each) in 19-29 years and 30-39 years followed by (26.7%, 4/15) in 40-49 years age group. Among HCV- coinfected patients, 80% (n=12) were reported as low level education; 20% (n=3) as high level education and more common in urban (53.3%, 8/15) than rural area (46.7%, 7/15). Coinfection with HCV was in statistically significant association (p<0.05) with IVDU history (57.1%, 8/14). Out of 52 patients with history of skin piercing, anti-HCV was detected in 17.3% (n=9). Among HCV-coinfected patients, mean CD4 count was 493.87 cells/mm3. No HCV coinfection was encountered in patients with CD4 count <200 cells/mm3. The present study demonstrated that HCV coinfection was more common in male, residents from urban area, married people, low education and history of body piercing practice. The findings of this study would be indicative of a portion of hepatitis C coinfection among HIV patients in Myanmar.



SUBJECT HEADINGS:   Anti-HCV, Coinfection, HIV, Seroprevalence, ELISA
FULL TEXT:  

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Coinfection with hepatitis C virus in HIV-infected individuals results in increased hepatic complications. In the era of antiretroviral therapy, liver-related death among HIV patients is the most prevalent non-AIDS related cause. HIV and HCV share common pathways of mode of transmission. The aim of this study was to detect hepatitis C in HIV patients and to find out the coinfection rate in HIV patients from Mingalardon Specialist Hospital. The study was done at Molecular Technology Applications Division at Department of Medical Research from January 2016 to December 2016. A total of 150 participants including 83 males and 67 females were studied. Blood samples were tested for anti-HCV by enzyme-linked immunosorbent assay (ELISA) method. Anti-HCV was positive in 15 (9 males, 6 females) and the prevalence rate was found to be 10%. Anti-HCV positivity was found (33.3%, 5/15 each) in 19-29 years and 30-39 years followed by (26.7%, 4/15) in 40-49 years age group. Among HCV- coinfected patients, 80% (n=12) were reported as low level education; 20% (n=3) as high level education and more common in urban (53.3%, 8/15) than rural area (46.7%, 7/15). Coinfection with HCV was in statistically significant association (p<0.05) with IVDU history (57.1%, 8/14). Out of 52 patients with history of skin piercing, anti-HCV was detected in 17.3% (n=9). Among HCV-coinfected patients, mean CD4 count was 493.87 cells/mm3. No HCV coinfection was encountered in patients with CD4 count <200 cells/mm3. The present study demonstrated that HCV coinfection was more common in male, residents from urban area, married people, low education and history of body piercing practice. The findings of this study would be indicative of a portion of hepatitis C coinfection among HIV patients in Myanmar.


Subject Headings : Anti-HCV, Coinfection, HIV, Seroprevalence, ELISA Full Text : 04 Dr. Tin Sandar Win.pdf -->

Vision : Achieving a healthier nation through application of research findings          Mission Statement : To Develop and promote solutions to the major health problems of Myanmar