Original Articles 2012-02-20

The Use of Herbal Medicine and Traditional Medicine Formulations (TMFs) for Hypertension at Traditional Medicine Hospital, Yangon

This study was done to determine the use of herbal medicines and Traditional Medicine Formulations (TMFs) for treating hypertension at Outpatients' Department (OPD) of Traditional Medicine Hospital, Yangon. This study was a cross-sectional, descriptive study in 140 hypertensive patients attending th

Original Articles 2020-09-11

Is Community Intervention Effective for Improving Maternal, Newborn and Child Health Care in Hard-to-Reach Areas of Chin State, Myanmar?

To tackle the maternal, newborn and child health (MNCH) care needs is a challenging situation in remote and hard-to-reach areas. Intervention activities focusing on strengthening community health care network through community participation and supporting Basic Health Staffs for MNCH ser

Original Articles 2020-09-14

Incidence of Snakebite in Four Townships of Yangon Region

The true incidence of snakebite in Myanmar is unknown. The current data are based on hospital returns to Ministry of Health and Sports and they are likely to be under-reported. A community-based survey is useful to know the current burden of snakebite and thus for planning and formulating str

Next Prev

Aims of MHSR Journal

• To serve as an important medium for the publication of original research in the field of medical science and health research, thus filling gaps in health knowledge for effective utilization of research findings
• To impart current medical knowledge and updated scientific information obtained from research to health professionals for better and appropriate health care management
• To disseminate recent basic, applied and social research findings among health personnel of different strata for enhancing worldwide health development

Archives   2020

Myanmar   Health   Sciences   Research   Journal

Volume   32,  Number   1

TITLE:   Molecular Genotyping of Silent Beta Thalassaemia Carriers among the Healthy Adult Population in Yangon
AUTHOR:   Moh Moh Htun, Yin Min Htun, Than Than Aye, Myat Mon Oo, Than Than Swe, Khin Myo Set, Hnin Nu Htwe, Ohnmar & Hlaing Myat Thu
SOURCE:   Myanmar Health Sciences Research Journal, 2020; 32(1): 7-12
ABSTRACT:  

Beta thalassaemia trait (minor) or heterozygous carrier type has one beta globin gene defect that may be asymptomatic or cause slight anemia. Molecular genetic testing of the gene encoding the hemoglobin subunit beta (HBB) represents advanced method for detection of pre-symptomatic or silent beta thalassaemia carrier in at-risk family members and for prenatal diagnosis. Out of 516 healthy adults (age 16-45 years) living in Yangon, 103 have anemia (Hb <12g%). Twenty-one (4%) of beta thalassaemia carriers were detected by osmotic fragility test (OFT), HbF% and HbA 2% estimations were done by high performance liquid chromatography (HPLC) and emoglobinopathies were observed by iso-electric focusing gel electrophoresis (IEF). HBB gene mutation was detected in 52 adults (10%) by using polymerase chain reaction with single strand conformation polymorphism (PCR-SSCP). The most common HBB gene mutation was CD26G>A (HbE) (66.7%). The other common five genetic mutations were CD35C>A, CD6A>T (HbS), CD71/72+A, CD17A>T and IVSII 654C>T that were diagnosed as silent beta thalassaemia carriers. Molecular screening for HBB mutation is a sensitive test and easy technique to detect silent beta thalassaemia carriers among healthy adult population after testing of essential red blood cells parameters (Hb%, MCV, MCH, RDW) by automatic blood analyzer and morphology of red blood cell by blood film examination. Screening of thalassaemia carriers and providing the proper health education in adult population are part of main strategies for prevention and control of new cases of thalassaemia major in Myanmar.