- To serve as an important medium for the publication of original research in the field of medical science and health research, thus filling gaps in health knowledge for effective utilization of research findings
- To impart current medical knowledge and updated scientific information obtained from research to health professionals for better and appropriate health care management
- To disseminate recent basic, applied and social research findings among health personnel of different strata for enhancing worldwide health development
Archives 2019
Myanmar Health Sciences Research Journal
Volume 31, Number 2
TITLE: Molecular Diagnosis of Atypical Pneumonia Infection in Children Presenting with Acute Respiratory Tract Infection Attending Yangon Children’s Hospital
AUTHOR: Hpoo Pwint Myo Win, Wah Wah Aung, Lay Myint Yoshida, Han Win, Ohnmar Aung, Wah Win Htike, Mya Mya Aye, Ssu Wynn Mon & Ye Myint Kyaw
SOURCE: Myanmar Health Sciences Research Journal, Vol. 31, No. 2, 2019
ABSTRACT: Acute respiratory tract infection (ARI) is a clinical condition which causes high morbidity and mortality, especially in infants and
young children. Pneumonia is a common complication of respiratory
tract infection. Atypical pneumonia, which is commonly caused
by Mycoplasma pneumoniae, Chlamydophila pneumoniae and Legi-onella pneumophila, is difficult to be detected because the causal bacteria cannot be diagnosed by routine culture method and presenting with non-specific clinical symptoms. This study aimed to diagnose the atypical pneumonia infection in children presenting with ARI attending Yangon Children’s Hospital during 2014-15 by using multiplex polymerase chain reaction (M-PCR). The bacterial DNA was extracted from nasopharyngeal swab samples by using Qiagen DNA minikit and detected by M-PCR. Of 245 patients with ARI, 140(57%) were males and 105(43%) were females. Eleven samples (4.4%) were positive for atypical pneumonia infection, among which 4(1.6%) were Mycoplasma pneumoniae,5(2%) were Chlamydophila pneumoniae and 2(0.8%) were Legionella pneumophila. The atypical pneumonia cases were mostly seen among the age of 1 to 5 years and sex distribution was nearly equal. The infected cases were detected from pneumonia (36.4%), severe pneumonia (27.3%), viral-induced wheeze (18.2%), severe bronchiolitis (9.1%) and bronchiolitis (9.1%). This study highlights the role of atypical pneumonia infection in ARI cases among children.
SUBJECT HEADINGS: Atypical pneumonia infection in children
FULL TEXT: