Original Articles 2012-02-20

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Original Articles 2020-09-11

Is Community Intervention Effective for Improving Maternal, Newborn and Child Health Care in Hard-to-Reach Areas of Chin State, Myanmar?

To tackle the maternal, newborn and child health (MNCH) care needs is a challenging situation in remote and hard-to-reach areas. Intervention activities focusing on strengthening community health care network through community participation and supporting Basic Health Staffs for MNCH ser

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Incidence of Snakebite in Four Townships of Yangon Region

The true incidence of snakebite in Myanmar is unknown. The current data are based on hospital returns to Ministry of Health and Sports and they are likely to be under-reported. A community-based survey is useful to know the current burden of snakebite and thus for planning and formulating str

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Aims of MHSR Journal

• To serve as an important medium for the publication of original research in the field of medical science and health research, thus filling gaps in health knowledge for effective utilization of research findings
• To impart current medical knowledge and updated scientific information obtained from research to health professionals for better and appropriate health care management
• To disseminate recent basic, applied and social research findings among health personnel of different strata for enhancing worldwide health development

Archives   2018

Myanmar   Health   Sciences   Research   Journal

Volume   30,  Number   3

TITLE:   Immunoexpression of Bcl-2 in B-cell Non-Hodgkin Lymphoma
AUTHOR:   May Thu Lwin, Saw Nu Nu Hlaing, San San Hlaing, Moe Hein, Nyein Chan Khin & Yadanar Htay
SOURCE:   Myanmar Health Sciences Research Journal, Vol. 30, No. 3, 2018
ABSTRACT:   The purpose of this study was to determine immunoexpression of Bcl-2 in B-cell Non-Hodgkin Lymphoma (NHL). This was a hospital-based, cross-sectional descriptive study involving forty patients of B-cell NHL admitted to Mandalay General Hospital. All cases were subclassified into low, intermediate and high grade according to Working Formulation on haematoxylin & eosin examination. Immunohistochemistry study using rabbit monoclonal Anti-Bcl-2 antibodies (BioGenex) was done on all cases by HRP (horseradish peroxidase polymer) method at the Common Research Laboratory, University of Medicine (Mandalay). In this study, the age distribution of B-cell NHL ranged from 13 to 80 years and the peak was between 41-60 years age group. Male to female ratio was 1:1.3. Out of 40 cases, 22(55%) were nodal NHL and 18(45%) were extranodal NHL. According to Working Formulation, 5 cases (12.5%) were low grade, 33 cases (82.5%) were intermediate grade, and 2 cases (5.0%) were high grade. Most of the cases were diffuse large B-cell lymphoma. Immunoexpression of Bcl-2 in all 40 cases showed that 38 cases (95.0%) were Bcl-2 positive and 2 cases (5.0%) of diffuse large cell NHL were Bcl-2 negative. There was no obvious difference between Bcl-2 immuno-expression in both nodal and extranodal B-cell NHL. Positive Bcl-2 immunoexpression was found 100% in low grade (5/5 cases), 94% in intermediate grade (31/33 cases) and 100% in high grade (2/2 cases). In conclusion, Bcl-2 was expressed frequently in B-cell NHL. Majority of the cases were intermediate grade, diffuse large cell type. Bcl-2 immunostaining can find out follicular lymphoma indicating that it must be considered as routine Immunohistochemistry (IHC) marker in B-cell NHL. It is also needed to study identification and the role of Bcl-2 in prognosis and treatment of B-cell NHL by adding more IHC markers in large population with longer duration.
SUBJECT HEADINGS:   B-cell Non-Hodgkin Lymphoma, Bcl-2
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