Myanmar Health Sciences Research Journal
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Aims of MHSR Journal
  • To serve as an important medium for the publication of original research in the field of medical science and health research, thus filling gaps in health knowledge for effective utilization of research findings
  • To impart current medical knowledge and updated scientific information obtained from research to health professionals for better and appropriate health care management
  • To disseminate recent basic, applied and social research findings among health personnel of different strata for enhancing worldwide health development


Archives   2018

Myanmar   Health   Sciences   Research   Journal

Volume   30,  Number   3

TITLE:   Comparison of Clinical and Virological Characteristics among Infants, Children and Adults with Dengue Infection during 2015 Dengue Outbreak
AUTHOR:   Theingi Win Myat, Hlaing Myat Thu,Ye Myint Kyaw, Khin Saw Than, Hlaing Mya Win, Zaw Than Tun, Htin Lin, Win Kay Khine & Kyaw Zin Thant
SOURCE:   Myanmar Health Sciences Research Journal, Vol. 30, No. 3, 2018
ABSTRACT:   Dengue is one of the important causes of serious illness and death in children. Recently, dengue hemorrhagic fever/dengue shock syndrome was reported to occur in infants and a shift to older age group was also reported from many countries. In Myanmar, dramatic increase in hospitalization of dengue cases was noticed starting from June, 2015 in all ages and was regarded as an outbreak year. Therefore, this study was conducted with the aim to determine and compare the clinical and virological characteristics of dengue infection in infants, children and adults during 2015 outbreak. A total of 682 blood samples were collected from clinically diagnosed dengue patients admitted to Yangon Children’s Hospital and Yangon General Hospital between June and October, 2015. Among them, 25/43 (58%), 317/548 (58%) and 44/91 (48%) were serologically confirmed dengue infections in infants, children and adults, respectively. Secondary dengue infection was more common in adults (66%) whereas primary dengue infection accounted up to 88% in infants and the association is statistically significant (p<0.05). Regarding age distribution, 6-9 months group within infants (76%), 4-9 years group within children (53%) and 12-19 years group within adults (66%) were significantly higher than other age groups. The highest proportion of infant cases was DHF I (88%),whereas that of adults was DHF II (48%) and DSS accounted up to 27% in children. Upon serotyping by virus isolation and Reverse Transcriptase PCR method, virus was detected in 28 samples. Among them, 21(75%) was DENV 1, 2(7%) was DENV 2, 1(4%) was DENV 3 and 4(14%) was mixed serotypes. DENV 1 was more frequent in DHF I and II cases and all DENV 2 detected were from DSS cases.
SUBJECT HEADINGS:   Dengue infection, Clinical characteristics of dengue, Dengue serotype, Adult dengue, Infant dengue
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Vision : Achieving a healthier nation through application of research findings          Mission Statement : To Develop and promote solutions to the major health problems of Myanmar