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Aims of MHSR Journal

• To serve as an important medium for the publication of original research in the field of medical science and health research, thus filling gaps in health knowledge for effective utilization of research findings
• To impart current medical knowledge and updated scientific information obtained from research to health professionals for better and appropriate health care management
• To disseminate recent basic, applied and social research findings among health personnel of different strata for enhancing worldwide health development

Archives   2018

Myanmar   Health   Sciences   Research   Journal

Volume   30,  Number   3

TITLE:   Hepatoprotective Effect of Ethanolic Extract of Andrographis paniculata Nees. (say-gha-gyi) Leaves on Paracetamol-induced Hepatotoxicity in Albino Rats
AUTHOR:   Ei Mon Mon Hlaing, Myint Myint Than, Khin Phyu Phyu & Nu Nu Aye
SOURCE:   Myanmar Health Sciences Research Journal, Vol. 30, No. 3, 2018
ABSTRACT:   Andrographis paniculata Nees. (say-gha-gyi) is a medicinal plant tradition-ally used as hepatoprotective agent and grows wild throughout Myanmar. The aim of this study was to evaluate scientifically the hepato-protective effect of Andrographis paniculata Nees. leaves on paracetamol-induced hepatotoxicity in albino rats. Andrographis paniculata Nees. leaves were extracted with 50% ethanol. To induce hepatotoxicity, oral paracetamol(0.5 g/kg) was used. To investigate hepatoprotective effect, thirty albino rats (250-300 g) were divided into five groups, group I served as normal control (distilled water only), group II was kept as paracetamol control and group III, IV and V served as tested groups, receiving oral administration of 200, 300 and 400 mg/kg of the 50% ethanol extract, respectively, daily up to 7th day. On the morning of 7th day, group II, III, IV and V received single dose of oral paracetamol (0.5 g/kg). After 48 hours of paracetamol admini-stration, the animals of all groups were sacrificed, and blood was collected. All doses of the ethanolic extract of Andrographis paniculata Nees. showed significantly lower ALT level than paracetamol control (p<0.001). Signifi-cant lower AST level than paracetamol control group was found with high dose of the extract 300 and 400 mg/kg receiving groups (p<0.001) and 200 mg/kg receiving group (p<0.01). High dose of extract 300 and 400 mg/kg receiving groups showed significant hepatoprotective effect in degeneration of liver when compared with paracetamol control (p<0.05). From these data, it showed that the 50% ethanolic extract of Andrographis paniculata Nees. leaves has some extent of hepatoprotective effect on paracetamol-induced hepatotoxicity in albino rats.
SUBJECT HEADINGS:   Andrographis paniculata Nees., Hepatoprotective effect, Paracetamol
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