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Archives 2018
Myanmar Health Sciences Research Journal
Volume 30, Number 3
TITLE: Hypoglycemic Effect of Terminalia chebula Retz. (Phan-kha-thee) on Diabetic Albino Rat Models
AUTHOR: Ei Pye Phyo Aung, Shin Hnaung Lwin, Khin Phyu Phyu & Nu Nu Aye
SOURCE: Myanmar Health Sciences Research Journal, Vol. 30, No. 3, 2018
ABSTRACT: This study was aimed to evaluate the hypoglycemic effect of ethanolic extract of Terminalia chebula Retz. fruits (Phan-kha-thee) on diabetic albino rats. In first part, a randomized controlled experimental animals study was done. The 80% - ethanolic extraction of fruits of Terminalia chebula Retz. was done by using Soxhlet apparatus. Diabetes mellitus was induced in wistar albino rats by intraperitoneal injection of alloxan (100 mg/kg).The extracts (100, 200 and 400 mg/kg) and metformin were orally administered to rats for 28 days. Fasting blood glucose (FBG) levels were measured weekly using glucometer. At the end of first, second, third and fourth weeks, the FBG levels of diabetic group were 325.7±28.2 mg/dl, 308.5±69.8 mg/dl, 322.7±65.8 mg/dl and 369.2±57.4 mg/dl, those of metformin (100 mg/kg) group were 76.2±9.5 mg/dl, 92.5±14.9 mg/dl, 94.5±17.9 mg/dl and
90.8±9.9 mg/dl, those of the Terminalia chebula Retz. extract 100 mg/kg group were 232.5±78.6 mg/dl, 122.8±41.4 mg/dl, 109.2±33.6 mg/dl and 132.3±41.1 mg/dl, respectively. When all treatment groups compared with diabetic group, the FBG levels were significantly reduced (p<0.001). There was no significant difference in FBG levels between metformin group and extract (200 and 400 mg/kg) groups. In second part, Quasi experimental study was done in maltose-induced models. Acarbose (18.5 mg/kg) and extract (100, 200 and 400 mg/kg) were orally administered first and maltose 2 g/kg was also administered after 10 minutes apart. Blood glucose concentrations were measured at 0, 30, 60, 90 and 120 minutes by glucometer. There was no significant difference between that acarbose and that of the extract 200 mg/kg. The ethanolic extract has significant hypoglycemic effect on alloxan-induced diabetic rats and its action is comparable to metformin.
SUBJECT HEADINGS: Terminalia chebula Retz., Hypoglycemic effect, Alloxan-induced diabetic rats, Maltose-induced models
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