Original Articles 2012-02-20

The Use of Herbal Medicine and Traditional Medicine Formulations (TMFs) for Hypertension at Traditional Medicine Hospital, Yangon

This study was done to determine the use of herbal medicines and Traditional Medicine Formulations (TMFs) for treating hypertension at Outpatients' Department (OPD) of Traditional Medicine Hospital, Yangon. This study was a cross-sectional, descriptive study in 140 hypertensive patients attending th

Original Articles 2020-09-11

Is Community Intervention Effective for Improving Maternal, Newborn and Child Health Care in Hard-to-Reach Areas of Chin State, Myanmar?

To tackle the maternal, newborn and child health (MNCH) care needs is a challenging situation in remote and hard-to-reach areas. Intervention activities focusing on strengthening community health care network through community participation and supporting Basic Health Staffs for MNCH ser

Original Articles 2020-09-14

Incidence of Snakebite in Four Townships of Yangon Region

The true incidence of snakebite in Myanmar is unknown. The current data are based on hospital returns to Ministry of Health and Sports and they are likely to be under-reported. A community-based survey is useful to know the current burden of snakebite and thus for planning and formulating str

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Aims of MHSR Journal

• To serve as an important medium for the publication of original research in the field of medical science and health research, thus filling gaps in health knowledge for effective utilization of research findings
• To impart current medical knowledge and updated scientific information obtained from research to health professionals for better and appropriate health care management
• To disseminate recent basic, applied and social research findings among health personnel of different strata for enhancing worldwide health development

Archives   2017

Myanmar   Health   Sciences   Research   Journal

Volume   29,  Number   1

TITLE:   Determination of Serum Aflatoxin B1 (Biomarker) Adducts in Chronic Liver Disease Patients Attending in 500 Bedded Specialty Hospital, Yangon
AUTHOR:   Myat Mon Oo, Moh Moh Htun, Zayar Chit, Hnin Nu Htwe, Yi Yi Kyaw, Win Maw Tun, Mya Ohnmar, Hlaing Myat Thu & Win Naing
SOURCE:   Myanmar Health Sciences Research Journal, Vol. 29, No. 1, 2017
ABSTRACT:   Hepatocellular carcinoma and cirrhosis of liver diseases are common cases in the Department of Hepatology, 500 bedded Specialty Hospital, Yangon. Obesity and diabetes are closely associated with liver abnormality called Non Alcoholic Fatty Liver Disease (NAFLD) that may increase the risk of liver cancer. Environmental exposure to aflatoxin is one of the risk factors for development of liver cancer in underling chronic liver disease. A cross-sectional, hospital- and laboratory-based study was carried out on total 91 chronic liver disease patients (75 males and 16 females with mean age of 50±11 years) including 35 hepatocellular carcinoma (HCC) cases and 56 cirrhosis of liver (COL) cases attending the Department of Hepatology, 500 Bedded Specialty Hospital, Yangon. This study was aimed to determine AFB1-albumin adduct level in serum of all subjects by using enzyme-linked immunosorbent assay (Bio Scientific ELISA kit). The minimum detection level of AFB1 was 0.25 ng/ml in this ELISA kit. AFB1 was not detected in serum of 10 normal healthy subjects in this study. AFB1 was detected in 4 cases (11.4%) of HCC and 4 cases (7.1%) of COL. Mean AFB1 concentration was higher in HCC cases (0.38±0.09 ng/ml) than in COL cases (0.28±0.03 ng/ml). The number of hepatitis B virus surface antigen (HBsAg) positive cases were significantly higher (21, 60%) in HCC cases than in COL cases (16, 29%), (p<0.05). There was no significant difference in anti-HCV positive cases between two types of chronic liver diseases such as 11(31%) in HCC and 17(30%) in COL, respectively. All HCC cases with AFB1 positivity had markers of hepatitis B and C but three cases of COL with AFB1 positivity had no markers for hepatitis B and C. In this study, hepatitis B and C viral infections are main causes of hepatocellular carcinoma and aflatoxin B1 may be one of the risk factor for development of cirrhosis liver without hepatitis viral infections.
SUBJECT HEADINGS:   Hepatocellular carcinoma, Cirrhosis of liver diseases, AFB1-albumin adduct level, ELISA
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