Original Articles 2012-02-20

The Use of Herbal Medicine and Traditional Medicine Formulations (TMFs) for Hypertension at Traditional Medicine Hospital, Yangon

This study was done to determine the use of herbal medicines and Traditional Medicine Formulations (TMFs) for treating hypertension at Outpatients' Department (OPD) of Traditional Medicine Hospital, Yangon. This study was a cross-sectional, descriptive study in 140 hypertensive patients attending th

Original Articles 2020-09-11

Is Community Intervention Effective for Improving Maternal, Newborn and Child Health Care in Hard-to-Reach Areas of Chin State, Myanmar?

To tackle the maternal, newborn and child health (MNCH) care needs is a challenging situation in remote and hard-to-reach areas. Intervention activities focusing on strengthening community health care network through community participation and supporting Basic Health Staffs for MNCH ser

Original Articles 2020-09-14

Incidence of Snakebite in Four Townships of Yangon Region

The true incidence of snakebite in Myanmar is unknown. The current data are based on hospital returns to Ministry of Health and Sports and they are likely to be under-reported. A community-based survey is useful to know the current burden of snakebite and thus for planning and formulating str

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Aims of MHSR Journal

• To serve as an important medium for the publication of original research in the field of medical science and health research, thus filling gaps in health knowledge for effective utilization of research findings
• To impart current medical knowledge and updated scientific information obtained from research to health professionals for better and appropriate health care management
• To disseminate recent basic, applied and social research findings among health personnel of different strata for enhancing worldwide health development

Archives   2017

Myanmar   Health   Sciences   Research   Journal

Volume   29,  Number   1

TITLE:   Multidrug-resistant Mycobacterium tuberculosis Strains in Myanmar Patients
AUTHOR:   Thanda Tun, Kyi Kyi Thinn, Khin Saw Aye, Win Win Yee, Naw Eh Khu Se, Khin Zaw Latt & Thandar Lwin
SOURCE:   Myanmar Health Sciences Research Journal, Vol. 29, No. 1, 2017
ABSTRACT:   Myanmar is one of the high MDR-TB burden countries globally. The aim of this study was to provide genetic information of MDR-TB strains from Myanmar. A total of 139 high-positive sputum samples (i.e., AFB grade 2+ or 3+) from MDR-TB suspected cases which were referred to National TB Reference Laboratory, Yangon during 2012-2013 were included. GenoType MTBDRplus assay was used to detect resistance to rifampicin and isoniazid, and results were compared with phenotypic Lowenstein-Jensen proportion method at National TB Reference Laboratory, Yangon. Genotypes were also identified by spoligotyping method. The most common rifampicin resistance mutation was S531L (67.5%) in the rpoB gene and the most prevalent isoniazid resistance mutation was S315T (90.4%) in the katG gene. There was high agreement (kappa=0.934) between the MTBDRplus assay and phenotypic susceptibility results in detecting MDR-TB. The inhA C15T mutation was more likely to occur in isoniazid mono-resistant cases than in MDR-TB cases (p=0.038). Beijing genotype was predominantly identified in 76.4% of strains (55/72). Strains belonging to Beijing geno-types are significantly associated with MDR-TB (p=0.001) as well as resis-tance to isoniazid, rifampicin, streptomycin and ethambutol (all p<0.05). The katG S315T mutation was more likely to develop in strains of Beijing genotype (p=0.009). This study provides relevant data which can be applied for the development of new and better tools (diagnostics, therapeutics, vaccines) for effective measures in the control of drug-resistant tuberculosis in the country. It also gives information on the general anti-TB drug resistance status in Myanmar patients.
SUBJECT HEADINGS:   Multidrug resistant, Tuberculosis, Myanmar, Genotype, Mutation
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