Original Articles 2012-02-20

The Use of Herbal Medicine and Traditional Medicine Formulations (TMFs) for Hypertension at Traditional Medicine Hospital, Yangon

This study was done to determine the use of herbal medicines and Traditional Medicine Formulations (TMFs) for treating hypertension at Outpatients' Department (OPD) of Traditional Medicine Hospital, Yangon. This study was a cross-sectional, descriptive study in 140 hypertensive patients attending th

Original Articles 2020-09-11

Is Community Intervention Effective for Improving Maternal, Newborn and Child Health Care in Hard-to-Reach Areas of Chin State, Myanmar?

To tackle the maternal, newborn and child health (MNCH) care needs is a challenging situation in remote and hard-to-reach areas. Intervention activities focusing on strengthening community health care network through community participation and supporting Basic Health Staffs for MNCH ser

Original Articles 2020-09-14

Incidence of Snakebite in Four Townships of Yangon Region

The true incidence of snakebite in Myanmar is unknown. The current data are based on hospital returns to Ministry of Health and Sports and they are likely to be under-reported. A community-based survey is useful to know the current burden of snakebite and thus for planning and formulating str

Next Prev

Aims of MHSR Journal

• To serve as an important medium for the publication of original research in the field of medical science and health research, thus filling gaps in health knowledge for effective utilization of research findings
• To impart current medical knowledge and updated scientific information obtained from research to health professionals for better and appropriate health care management
• To disseminate recent basic, applied and social research findings among health personnel of different strata for enhancing worldwide health development

Archives   2015

Myanmar   Health   Sciences   Research   Journal

Volume   27,  Number   3

TITLE:   Acute and Sub-acute Toxicity of Allium sativum Linn. (Garlic) Bulbs in Animal Model
AUTHOR:   Khine Khine Lwin, Mu Mu Sein Myint, Moh Moh Htun, Khin Tar Yar Myint, Win Win Maw, San San Myint, Aung Aung Maw, Nu Nu Win & Myint Myint Khine
SOURCE:   Myanmar Health Sciences Research Journal, Vol. 27, No. 3, 2015
ABSTRACT:   Allium sativum Linn. (Garlic) (Family-Liliaceae) is one of the commonly used medicinal plants in Myanmar traditional medicine for the treatment of hypertension. The present study was carried out to determine the phyto-chemical constituents and to find out the acute and sub-acute toxicity of dried bulb powder of garlic on animal model. The acute toxicity test of the dried bulb powder was carried out in albino mice. In sub-acute toxicity study, the dried bulb powder in the doses of 300 mg/kg and 600 mg/kg were administered orally to the albino rats daily for 90 days. At the end of 90 days, all the rats were sacrificed. Blood samples of the rats were collected and tested for haematological and biochemical parameters. The internal organs were removed and collected for histopathological studies. It was found that the dried bulb powder contained alkaloids, flavonoids, glycosides, polyphenol, amino acid, steroid/terpene, glycoside, tannin, saponin, carbohydrate and resin. In the acute toxicity study, it was found that LD50 value of the bulb powder was more than 2 g/kg. In the sub-acute toxicity study, the dried bulb powder at the dose of 300 mg/kg and 600 mg/kg showed no significant changes in body weight, hematological (blood complete picture) and biochemical (serum creatinine and blood urea, liver function test) parameters when compared with those of the control group. Histopathological studies of the internal organs of the rats showed no pathological changes. Therefore, it can be concluded that the dried bulb powder of garlic had no acute toxic effect in the mice and sub-acute toxic effect in the rats.
SUBJECT HEADINGS:   Toxicity, Garlic bulbs, Animal model
FULL TEXT: