Original Articles 2012-02-20

The Use of Herbal Medicine and Traditional Medicine Formulations (TMFs) for Hypertension at Traditional Medicine Hospital, Yangon

This study was done to determine the use of herbal medicines and Traditional Medicine Formulations (TMFs) for treating hypertension at Outpatients' Department (OPD) of Traditional Medicine Hospital, Yangon. This study was a cross-sectional, descriptive study in 140 hypertensive patients attending th

Original Articles 2020-09-11

Is Community Intervention Effective for Improving Maternal, Newborn and Child Health Care in Hard-to-Reach Areas of Chin State, Myanmar?

To tackle the maternal, newborn and child health (MNCH) care needs is a challenging situation in remote and hard-to-reach areas. Intervention activities focusing on strengthening community health care network through community participation and supporting Basic Health Staffs for MNCH ser

Original Articles 2020-09-14

Incidence of Snakebite in Four Townships of Yangon Region

The true incidence of snakebite in Myanmar is unknown. The current data are based on hospital returns to Ministry of Health and Sports and they are likely to be under-reported. A community-based survey is useful to know the current burden of snakebite and thus for planning and formulating str

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Aims of MHSR Journal

• To serve as an important medium for the publication of original research in the field of medical science and health research, thus filling gaps in health knowledge for effective utilization of research findings
• To impart current medical knowledge and updated scientific information obtained from research to health professionals for better and appropriate health care management
• To disseminate recent basic, applied and social research findings among health personnel of different strata for enhancing worldwide health development

Archives   2015

Myanmar   Health   Sciences   Research   Journal

Volume   27,  Number   3

TITLE:   Lipid Lowering and Antioxidant Effects of Atorvastatin and Rosuvastatin in Myanmar Hypercholesterolemic Subjects
AUTHOR:   Nilar Win Htut, Win Win May & May Hla Thwin
SOURCE:   Myanmar Health Sciences Research Journal. 2015; 27(3): 174-179
ABSTRACT:   Hypercholesterolemia is a major risk factor for atherosclerosis. Atorvastatin is one of the routinely used statins and rosuvastatins, newest and efficacious statin, which is less frequently used in management of hypercholesterolemia in Myanmar. This study aimed to compare the lipid lowering effect and antioxidant effect {by measuring plasma malondialdehyde (MDA) level} of atorvastatin 10 mg with that of rosuvastatin 10 mg in Myanmar hypercholesterolemic subjects for 6 weeks therapy. Community-based, interventional study was done in North Okkalapa Township, in which forty-two hypercholesterolemic subjects screening blood total cholesterol (TC>200 mg/dl) were divided into two groups of equal number by randomized computerization. Serum TC, triglyceride (TG), high density lipoprotein (HDL) and MDA levels were measured. Low density lipoprotein (LDL) level was calculated. Lipid lowering and antioxidant effects of both drugs were not significantly different at baseline. After 6-week therapy, both atorvastatin and rosuvastatin significantly reduced TC (180.98±19.87 and 149.40±17.62 mg/dl, p<0.001), LDL (108.77±18.82 and 79.38± 15.49 mg/dl, p<0.001), TG (107.51±31.82 and 83.91±28.63 mg/dl, p<0.05), respectively and increased HDL (48.82±3.21 and 51.79±3.78 mg/dl, p<0.05), respectively. Although both drugs effectively reduced lipid profile, rosuvastatin significantly produced more reduction in lipid profile than atorvastatin. Both atorvastatin and rosuvastatin significantly reduced MDA (2.63±0.991 and 2.28±1.123 mol/L, p<0.05) and rosuvastatin produced significantly greater reduction than atorvastatin (p<0.05). Therefore, this study suggested that rosuvastatin can also be used as a firstline agent in atherosclerosis because of more efficacious lipid lowering effect and antioxidant (MDA lowering) effect than that of atorvastatin.
SUBJECT HEADINGS:   Atorvastatin, Rosuvastatin, Lipid lowering effect, Antioxidant effect, Malondialdehyde
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