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Aims of MHSR Journal

• To serve as an important medium for the publication of original research in the field of medical science and health research, thus filling gaps in health knowledge for effective utilization of research findings
• To impart current medical knowledge and updated scientific information obtained from research to health professionals for better and appropriate health care management
• To disseminate recent basic, applied and social research findings among health personnel of different strata for enhancing worldwide health development

Archives   1989

Myanmar   Health   Sciences   Research   Journal

Volume   1,  Number   3

TITLE:   Effect of heprin on Russell's viper venom envenomated experimental rabbits.
AUTHOR:   Than Than; Soe Soe; Khin Ei Han
SOURCE:   Myanmar Health Sciences Research Journal. 1989; 1(3): 139-143
ABSTRACT:   Effects of heparin were studied on 20 Russell's Viper Venom (RVV) envenomated rabbits. After injection with LD 100 dose of RVV, the experimental animals were divided into four groups. Group 1 rabbits were left untreated; in Group II antivenom treatment was given; in Group III antivenom plus heparin was administered intravenously and in Group IV heparin alone was given. Effectiveness of heparin therapy was assessed by comparing the changes in the blood screening tests of haemostasis such as prothrombin time (PT), activated partial thromboplastin time (APTT) and thrombin time (TT), survival rate, degree of congestion and haemorrhage in the kidneys, presence or abscence of fibrin deposition and acute tublar necrosis in the kidneys of different groups of animals. Results showed no significant differences in the blood tests and fibrin deposition in the kidneys. However, there is an increase in the survival rate, as well as reduction in the severity of congestion, haemorrhage and acute tubular necrosis of the kidneys in the rabbits treated with specific antivenoms (ASV) plus heparin (Group III) over that treated with antivenom alone (Group II) and heparin alone (Group IV).
SUBJECT HEADINGS:   Viper Venoms. Antivenins. Heparin. Clinical Trials. Russell's Viper.
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