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Is Community Intervention Effective for Improving Maternal, Newborn and Child Health Care in Hard-to-Reach Areas of Chin State, Myanmar?

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Incidence of Snakebite in Four Townships of Yangon Region

The true incidence of snakebite in Myanmar is unknown. The current data are based on hospital returns to Ministry of Health and Sports and they are likely to be under-reported. A community-based survey is useful to know the current burden of snakebite and thus for planning and formulating str

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Aims of MHSR Journal

• To serve as an important medium for the publication of original research in the field of medical science and health research, thus filling gaps in health knowledge for effective utilization of research findings
• To impart current medical knowledge and updated scientific information obtained from research to health professionals for better and appropriate health care management
• To disseminate recent basic, applied and social research findings among health personnel of different strata for enhancing worldwide health development

Archives   1989

Myanmar   Health   Sciences   Research   Journal

Volume   1,  Number   3

TITLE:   Study of the effect of single dose primaquine on gametocytaemia and infectivity among Amodiaquine-treated P.falciparum malaria patients.
AUTHOR:   Tin Shwe; Khine Khine Win; Pe Than Myint
SOURCE:   Myanmar Health Sciences Research Journal. 1989; 1(3): 113-116
ABSTRACT:   One hundred and five patients who attended Thayarwady Civil Hospital during 1987 and 1988 malaria seasons were studied. They were divided into three groups. Among 35 patients who were treated with amodiaquine alone, 23-33% of the patients showed gametocytes in blood during days 14, 21 and 28 of therapy. Among those patients with gametocytes in blood, 50 to 63% of patients showed that they were viable by exflagellation method. Follow-up of one patient showed viable gametocytes in blood till 51st day of drug therapy. Among 45 patients treated with amodiaquine and primaquine (45 mg single dose given on day 3), 31% of patients showed gametocytes on day 7, later only 0-10% of patients showed gametocytes on day between 14, 21 and 28. Among the till day 4. From day 5 they were not viable. Except one patient who showed gametocytes at day 28 was proved to be R11 resistant to amodiaquine. Among 25 patients treated with amodiaquine and primaquine (45 mg single dose: given on day 1 of hospital admission) 36% showed gametocytes on day 7 and 42% showed gametocytes on day 28. Of these 26% patients with gametocytes which appeared on day 28 was proved to be viable. It is suggested that primaquine 45 mg is effective to control infectivity of gametocytes in blood. It is also suggested that primaquine should be given on 3rd day of hospital admission to get the most beneficial effect.
SUBJECT HEADINGS:   Malaria, Falciparum-drug therapy. Primaquine. Amodiaquine. Gametogenesis
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