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Archives 2003
Myanmar Health Sciences Research Journal
Volume 15, Number 1-3
TITLE: Neutralisation of biological activities of Russell's viper (Daboia russelii siamensis) Venoms from different localities of Myanmar by monospecific antivenom.
AUTHOR: Tun Pe; Aye Aye Myint; Kyi May Htwe
SOURCE: Myanmar Health Sciences Research Jpurnal. 2003; 15(1-3): 31-34
ABSTRACT: Neutralisation of biological properties of Russell's viper venoms from 5 divisions of Myanmar namely Mandalay, Magwe (Upper Myanmar), Yangon, Bago, Ayerawaddy (Lower Myanmar) by a monospecific antivenom was studied by WHO recommended methods of neutralisation in rodent. In general, 2 to 8 times more antivenom is required to neutralise different biological activities of the venoms of Upper Myanmar compared to the Lower. Forty times more antivenom is needed to neutralise procoagulant activity of the venom of Taungdwingyi (Magwe Division) compared to that of Daedaye (Ayerawaddy Division). The antivenom is equally effective in neutralising procoagulant activity of the venom of Wundwin (Mandalay division). Variable neutralisation of the properties of venom by the antivenom among venoms of Lower Myanmar is probably due to intra divisional variation in venom properties. The observation calls for use of widely pooled venoms it raising antivenom for common use.
SUBJECT HEADINGS: Russell's Viper. Antivenins. Viper Venoms. Neutralization Tests.
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