- To serve as an important medium for the publication of original research in the field of medical science and health research, thus filling gaps in health knowledge for effective utilization of research findings
- To impart current medical knowledge and updated scientific information obtained from research to health professionals for better and appropriate health care management
- To disseminate recent basic, applied and social research findings among health personnel of different strata for enhancing worldwide health development
Archives 2003
Myanmar Health Sciences Research Journal
Volume 15, Number 1-3
TITLE: Efficacy of the new batches of monospecific Russell's viper (Daboia russelii siamensis) and cobra (Naja kaouthia) antivenom manufactured by Myanmar Pharmaceutical Factory.
AUTHOR: Tun Pe; Aye Aye Myint; Kyi May Htwe
SOURCE: Myanmar Health Sciences Research Journal. 2003; 15(1-3): 13-15
ABSTRACT: Efficacy of new batch of monospecific Russell's viper (Dahoia russelii siamensis) and cobra (Najo kaouthia) antivenoms manufactured by the Myanmar Pharmaceutical Factory was tested according to WHO recommended techniques. The new batch of monospecific Russell's viper antivenom is 1.7 to 5 times less effective in neutralising defibrinogenating, haemorrhagic, necrotic, lethal and procoagu/ant activities and 64 times in capillary permeability increasing activity compared to the reference. The efficacy of neutralisation of the lethal activity of cobra venom by the new batch of monospecific cobra antivenom is 10 times inferior to that of the reference. Because of inferior performance of the new batch of antivenoms, clinical efficacy and the dose of the antivenom to be given to human snakebite cases need to be studied.
SUBJECT HEADINGS: Russell's Viper. Cobra Venoms. Antivenins.
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