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Archives 2005
Myanmar Health Sciences Research Journal
Volume 17, Number 3
TITLE: Drug resistance among tuberculosis patients who sought care at private sector before taking treatment at public health service.
AUTHOR: Wah Wah Aung; Ti Ti; Kyu Kyu Than; Myat Thida; Aye Aye Maw; Ah Mar Sein; Mar Mar Nyein; Win Maung; Aye Tun
SOURCE: Myanmar Health Sciences Research Journal. 2005; 17(3): 164-169
ABSTRACT: As drug resistant tuberculosis (TB) is an emerging problem, delay in achieving correct diagnosis and effective treatment may lead to occurrence of drug resistant cases.This study aimed to explore the bacteriological factor of TB patients who had considerable delay while seeking treatment at private sector (general practitioners, traditional healers, self proclaimed healers) before taking treatment at public health service (TB Clinic under National TB Programme). New sputum smear positive pulmonary TB patients attending TB Centre, Yangon Division were divided into two groups as direct patients (patients attending TB Centre directly and those taking treatment at private sector for <3 weeks before reaching TB Centre) and indirect patients (patients taking treatment at private sector for >3 weeks before TB Centre). Drug susceptibility testing of Mycobacterium tuberculosis strains isolated from 140 direct patients and 140 indirect patients was carried out to determine bacteriological contributing factor. Resistance to at least one of anti-TB drugs was documented in 15(10.71%) direct patients and 31(22.14%) indirect patients. Mono-resistance (resistance to one drug) was noted in 6(4.29%) direct patients and 16(11.43%) indirect patients. Poly-resistance (resistance totwo or more drugs) was noted in 9(6.49%) direct patients including 3(2.14%) multi-drug resistant cases (resistance to at least isoniazid and rifampicin) and 15(10.71%) indirect patients including12(8.57%) multi-drug resistant cases. Any anti-TB drug and multi drug resistant rates were significantly higher in indirect than in direct patients (P<0.05). This study highlighted that patients who had considerable delay while seeking treatment in private sectors before reaching public health service have greater opportunity for occurrence of drug resistance.
SUBJECT HEADINGS: Drug Resistance. Tuberculosis.
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