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Original Articles 2020-09-11

Is Community Intervention Effective for Improving Maternal, Newborn and Child Health Care in Hard-to-Reach Areas of Chin State, Myanmar?

To tackle the maternal, newborn and child health (MNCH) care needs is a challenging situation in remote and hard-to-reach areas. Intervention activities focusing on strengthening community health care network through community participation and supporting Basic Health Staffs for MNCH ser

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Incidence of Snakebite in Four Townships of Yangon Region

The true incidence of snakebite in Myanmar is unknown. The current data are based on hospital returns to Ministry of Health and Sports and they are likely to be under-reported. A community-based survey is useful to know the current burden of snakebite and thus for planning and formulating str

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Aims of MHSR Journal

• To serve as an important medium for the publication of original research in the field of medical science and health research, thus filling gaps in health knowledge for effective utilization of research findings
• To impart current medical knowledge and updated scientific information obtained from research to health professionals for better and appropriate health care management
• To disseminate recent basic, applied and social research findings among health personnel of different strata for enhancing worldwide health development

Archives   2005

Myanmar   Health   Sciences   Research   Journal

Volume   17,  Number   3

TITLE:   A preliminary study of the immune response to locally produced recombinant hepatitis B vaccine in adult volunteers.
AUTHOR:   Khin May Oo; Moh Moh Htun; Win Maw Tun; Kyin Kyin San; Nyein Nyein; Kay Khine Soe; Tin Tin Myint; Khin Pyone Kyi
SOURCE:   Myanmar Health Sciences Research Journal. 2005; 17(3): 154-158
ABSTRACT:   The immune response to locally produced recombinant hepatitis B vaccine was studied on 17 male adult volunteers.All subjects were negative for the hepatitis B markers namely hepatitis B surface antigen (HBsAg) and antibody to HBsAg (anti-HBs).Three doses of recombinant hepatitis B vaccine were given at 0, 1, 2 month intervals by intramuscular (IM) route.Eleven subjects were given 3 vaccinations of 20g per dose and 6 subjects were vaccinated with 40g of recombinant hepatitis B vaccine as the initial dose and 20g for the subsequent second and third doses.Blood samples were collected from each subject at 1, 2, 3 month intervals and tested for the presence of anti-HBs using the SD Anti-HBs ELISA 3.0, Standard Diagnostic, Korea.A known anti-HBs positive serum (400 m IU/ml) was used as the Working Standard.Anti-HBs was present in 23.5% of subjects one month after the first dose, 52.9% after the second dose and 88.2% after the third dose. The anti-HBs values ranged from 2 - 72 m IU/ml and protective anti-HBs levels (more than 10 m IU/ml) were achieved in 76.5% of the vaccinees at the end of 3 months.From this preliminary study, it could be concluded that the locally produced recombinant hepatitis B vaccine is immunogenic in human subjects.
SUBJECT HEADINGS:   Hepatitis B Vaccines.
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