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Aims of MHSR Journal

• To serve as an important medium for the publication of original research in the field of medical science and health research, thus filling gaps in health knowledge for effective utilization of research findings
• To impart current medical knowledge and updated scientific information obtained from research to health professionals for better and appropriate health care management
• To disseminate recent basic, applied and social research findings among health personnel of different strata for enhancing worldwide health development

Archives   2005

Myanmar   Health   Sciences   Research   Journal

Volume   17,  Number   3

TITLE:   Effect of pomegranate juices supplementation on serum total cholesterol level of hypercholesterolemic rats.
AUTHOR:   Theingi Thwin; Thet Thet Mar; Hnin Lwin Htun; Khin Than Yee; Lwin Zar Maw; Tin Ko Ko Oo; Aye Myint Oo; Khin Myat Tun
SOURCE:   Myanmar Health Sciences Research Journal. 2005; 17(3): 142-148
ABSTRACT:   To investigate the effect of pomegranate (Punica granatum) juice on serum total cholesterol level in an animal model, an experimental study was carried out in twenty Wistar strain rats (10 males and 10 females, 200-250 gm body weight,). To induce hypercholesterolemia, all rats were supplemented with a high cholesterol diet which was enriched with coconut oil, cholesterol and sugar (25%, 1%, and 16% by weight, respectively) to the ordinary feed for thirty days. After dietary inducement, ten of twenty hypercholesterolemic rats whose serum total cholesterol levels increasedby 75% and above 75% than their basal levels were administered orally, an alcohol extract of pomegranate seeds (0.056 gm) and 3 ml of fresh pomegranate juice (PJ) daily for ninety days. Another ten hypercholesterolemic rats (control group) were administered orally, 3 ml of distilled water daily for ninety days. Serum total cholesterol levels were measured on Day 30, Day 60, and Day 90 of pomegranate juice and distilled water supplementation. Serum total cholesterol levels of the test group were lower than those of the control group on Day 30 (91.44 22.9 mg/dl vs 109.4 27.19 mg/dl), and on Day 60 (82.617.3 mg/dl vs 89.713.96 mg/dl) of supplementation, although they were not statistically significant (p>0.05 for both). On Day 90 of supplementation, serum total cholesterol level of test group was significantly lower than that of control group (74.4 10.11 mg/dl vs 86.8 10.52mg/dl), (p=0.043). Therefore, a 90-day supplementation of PJ reduces serum total cholesterol level in diet-induced hypercholesterolemic rats.
SUBJECT HEADINGS:   Hypercholesterolemia. Cholesterol.
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