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Archives 2005
Myanmar Health Sciences Research Journal
Volume 17, Number 2
TITLE: Seroepidemiology on extended contacts of new leprosy cases in Nyaungdon Township.
AUTHOR: Khin Nwe Oo; Nwe Nwe Yin; Tin Tin Han; Kyaw Myint
SOURCE: Myanmar Health Sciences Research Journal. 2005; 17(2): 81-86
ABSTRACT: The contacts of the leprosy cases are risk groups to get acquire infection and develop disease after a long incubation period. Thus seroepidemiology was carried out on extended contacts of new leprosy cases in Nyaungdon Township, Ayeyawady Division. The prevalence rates of Ayeyawady Division and Nyaungdon Township were 1.52/10,000 and 1.8/10,000 respectively in 2002. There were 32 new leprosy cases (15 paucibacillary and 17 multibacillary) from September 2002 to August 2003.The study population was extended contacts of these new leprosy cases. The blood samples were collected from September to December 2003 after obtaining informed consent. Eight hundred and twenty nine (829) extended contacts were enrolled in this study. NTP-BSA ELISA test was carried out on their sera. Cut-off OD value was 0.120. Seropositivity rate of overall contacts was 309/829 (37.27%).In this study, seropositivity rate of overall contacts, household and neighbor contacts of both multibacillary (MB) and paucibacillary (PB) cases were similar. The seropositivity rate in children (40.35%) was more than the rate in adult contacts (36.49%), but it was not significant. The seropositivity rate of females (42.73%) was significantly increased compared to males i.e. 30.66%. Mostly mean antibody titer of household contacts (HC) was slightly more than neighbor contacts (NC) on both types. Those with high antibody level were much more likely to develop disease than those with low levels. Follow-up survey is needed to detect whether these contacts develop signs and symptoms of leprosy or have antibody titers persistently.
SUBJECT HEADINGS: Serologic Tests. Leprosy.
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