Original Articles 2012-02-20

The Use of Herbal Medicine and Traditional Medicine Formulations (TMFs) for Hypertension at Traditional Medicine Hospital, Yangon

This study was done to determine the use of herbal medicines and Traditional Medicine Formulations (TMFs) for treating hypertension at Outpatients' Department (OPD) of Traditional Medicine Hospital, Yangon. This study was a cross-sectional, descriptive study in 140 hypertensive patients attending th

Original Articles 2020-09-11

Is Community Intervention Effective for Improving Maternal, Newborn and Child Health Care in Hard-to-Reach Areas of Chin State, Myanmar?

To tackle the maternal, newborn and child health (MNCH) care needs is a challenging situation in remote and hard-to-reach areas. Intervention activities focusing on strengthening community health care network through community participation and supporting Basic Health Staffs for MNCH ser

Original Articles 2020-09-14

Incidence of Snakebite in Four Townships of Yangon Region

The true incidence of snakebite in Myanmar is unknown. The current data are based on hospital returns to Ministry of Health and Sports and they are likely to be under-reported. A community-based survey is useful to know the current burden of snakebite and thus for planning and formulating str

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Aims of MHSR Journal

• To serve as an important medium for the publication of original research in the field of medical science and health research, thus filling gaps in health knowledge for effective utilization of research findings
• To impart current medical knowledge and updated scientific information obtained from research to health professionals for better and appropriate health care management
• To disseminate recent basic, applied and social research findings among health personnel of different strata for enhancing worldwide health development

Archives   2005

Myanmar   Health   Sciences   Research   Journal

Volume   17,  Number   2

TITLE:   Tumour necrosis factor-alpha (TNF-à), interleukin-10 (IL-10) and interferongamma (IFN-grama) in leprosy.
AUTHOR:   Khin Saw Aye; Yin Thet Nu Oo; Ei Mon Thet; Kyi Kyi Aye; Kyaw Kyaw; Tin Maung Tsoh
SOURCE:   Myanmar Health Sciences Research Journal. 2005; 17(2): 62-65
ABSTRACT:   Leprosy is a chronic infectious disease characterized by a broad spectrum of clinical forms depending on the patient's immune response, in particular cell-mediated immune response. Cytokines can play a role in the cell-mediated immune response. Serum levels of Interferon-gamma ( IFN- ), Interleukin-10 (IL-10), Tumour Necrosis Factor (TNF-), were measured by enzyme-linked immunosorbent assay (ELISA) in 45 leprosy patients with reaction and 30 age and sex matched healthy controls. Significantly higher serum levels of the cytokines were detected in leprosy patients compared to controls. Serum cytokine levels of paucibacillary (PB) patients have significantly higher level of IFN-and TNF- than those of multibacillary (MB) patients. MB patients have significantly higher serum level of IL-10 than PB patients. Patients with type I reaction have high levels of IFN- and those of type II reaction have increased level of IL-10. In leprosy patients, IFN- and TNF- are immunoprotective and IL-10 is immunosuppressive. Results indicate that type I reaction is a cell mediated immune response and type II reaction is essentially an immunocomplex disease.
SUBJECT HEADINGS:   Tumor Necrosis Factor. Interleukin-10. Interferon Type II. Leprosy.
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