Myanmar Health Sciences Research Journal
Next Prev
Aims of MHSR Journal
  • To serve as an important medium for the publication of original research in the field of medical science and health research, thus filling gaps in health knowledge for effective utilization of research findings
  • To impart current medical knowledge and updated scientific information obtained from research to health professionals for better and appropriate health care management
  • To disseminate recent basic, applied and social research findings among health personnel of different strata for enhancing worldwide health development


Archives   2005

Myanmar   Health   Sciences   Research   Journal

Volume   17,  Number   2

TITLE:   Diagnosis of plasmodium falciparum infection from two different endemic areas by two immunological methods using glycophospholipid antigen.
AUTHOR:   Maung Maung Mya; Saxena, R.K; A.Roy; Roy, K.B; W.Tun Lin; Sein Min; Sein Thaung; Sein Maung Than; Kyaw Zaw
SOURCE:   Myanmar Health Sciences Research Journal. 2005; 17(2): 55-61
ABSTRACT:   Previously described isolated Glycophospholipid (GPL) antigen's diagnostic sensitivity and specificity properties were tested on malarial and non malarial blood samples from two different malaria endemic areas in Myanmar and India. The control area is a non-endemic area, Delhi, India. Standard Enzyme-Link Immunosorbent Assay (ELISA) and modified Laser Immunoassay (LIA) methods were used. The crude parasite rates were found to be 28.75% in Assam, India and 32.5% in Taikkyi, Myanmar respectively. P. falciparum was predominantly high in both forested-hilly areas. Immunoreactivity and specificity of GPL antigen were compared with those of another previously reported RESA derived synthetic peptide antigen (R1). The diagnostic sensitivity properties of GPL antigen were found cent percent sensitive for P. falciparum cases in both areas by LIA method but ELISA with R1 antigen showed a slightly lower level of sensitivity than GPL antigen. The specificity studies of GPL and R1 antigens tested on malarial and non malarial diseases sera were found to be very specific for P. falciparum as they did not react with other non malarial diseases sera. LIA method with the application of GPL coated latex beads can be an excellent diagnostic tool for Plasmodium falciparum infection.
SUBJECT HEADINGS:   Plasmodium falciparum. Antigens.
FULL TEXT:  

Back to Articles

Vision : Achieving a healthier nation through application of research findings          Mission Statement : To Develop and promote solutions to the major health problems of Myanmar