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Is Community Intervention Effective for Improving Maternal, Newborn and Child Health Care in Hard-to-Reach Areas of Chin State, Myanmar?

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The true incidence of snakebite in Myanmar is unknown. The current data are based on hospital returns to Ministry of Health and Sports and they are likely to be under-reported. A community-based survey is useful to know the current burden of snakebite and thus for planning and formulating str

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Aims of MHSR Journal

• To serve as an important medium for the publication of original research in the field of medical science and health research, thus filling gaps in health knowledge for effective utilization of research findings
• To impart current medical knowledge and updated scientific information obtained from research to health professionals for better and appropriate health care management
• To disseminate recent basic, applied and social research findings among health personnel of different strata for enhancing worldwide health development

Archives   2006

Myanmar   Health   Sciences   Research   Journal

Volume   18,  Number   3

TITLE:   Pharmacological effects on capillary permeability increasing activity of Russell's viper (Daboia russell's siamensis) venom (Short Report).
AUTHOR:   Kyi May Htwe; Tun Pe; Aye Aye Myint
SOURCE:   Myanmar Health Sciences Research Journal. 2006; 18(3): 163-164
ABSTRACT:   The pharmacological agents (0.1ml) dis-solved in normal saline in varying concentrations (saline alone for the control) were injected intraperitoneally into the rats one hour before venom challenge. One minimum capillary permeability increasing dose (MCPID) (0.007 µg/ml) of the venom was dissolved in normal saline and then 0.1 ml/dose of the venom was injected intradermally into two marked sections on the depilated dorsal skin of the rat 20 minutes before 2 ml intravenous injection of 1% Evan’s Blue dye (Sigma) in saline. Twenty minutes after the dye injection, the animal was sacrificed under light ether anaesthesia, then dorsal skin was removed and transverse diameter of the blue spots of the inner skin were measured in millimetre. Mean transverse diameters of four spots were recorded. The dose of the agent that gave 50% reduction of the diameter of the blue spot compared to the control (10x10 mm) was taken as end point. Three rats per dose were used and five doses with duplicate experiments were carried out for each pharmacological agent.
SUBJECT HEADINGS:   Russell's Viper. Permeability. Viper Venoms. Snake Bites.
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