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Aims of MHSR Journal

• To serve as an important medium for the publication of original research in the field of medical science and health research, thus filling gaps in health knowledge for effective utilization of research findings
• To impart current medical knowledge and updated scientific information obtained from research to health professionals for better and appropriate health care management
• To disseminate recent basic, applied and social research findings among health personnel of different strata for enhancing worldwide health development

Archives   2006

Myanmar   Health   Sciences   Research   Journal

Volume   18,  Number   3

TITLE:   Seasonal variation in biological and biochemical properties of Russell's viper (Daboia ruesslli siamensis) venom.
AUTHOR:   Aye Aye Myint; Tun Pe; Khin Aung Cho; Kyi May Htwe; Nu Nu Aung; Theingie
SOURCE:   Myanmar Health Sciences Research Journal. 2006; 18(3): 128-133
ABSTRACT:   Biological, biochemical and electrophoretic properties of venom of four captive Russell's vipers (Daboia russelli siamensis) milked monthly for 11-24 months were studied. In general, all biological activities such as lethal, coagulant, haemorrhagic, necrotic, defibrinogenating and capillary permeability increasing remained fairly stable within the first 3 months in captivity. Variation in activity (except haemorrhage and necrosis) was observed in captivity. Marked reduction in activity; (4-5 times) of lethal and defibrinogenating in July (raining) and November through January (winter) and coagulant ( 35 - 42 times) in April/May (summer) was observed. However, 4-7 times reduction in capillary permeability increasing activity (CPI) was recorded in July through September (raining). It is noteworthy that marked decrease in capillary permeability increasing activity was observed in two out of four Russell’s vipers from 3rd month onward following captivity. There was a variation in protein content, L-amino acid oxidase, esterolytic and phospholipase A2 activities in between seasons. However, no variation in venom yield was observed. Electrophoretic studies of venoms showed quantitative and qualitative variation in protein bands.
SUBJECT HEADINGS:   Russell's Viper. Viper Venoms. Snake Bites.
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