Original Articles 2012-02-20

The Use of Herbal Medicine and Traditional Medicine Formulations (TMFs) for Hypertension at Traditional Medicine Hospital, Yangon

This study was done to determine the use of herbal medicines and Traditional Medicine Formulations (TMFs) for treating hypertension at Outpatients' Department (OPD) of Traditional Medicine Hospital, Yangon. This study was a cross-sectional, descriptive study in 140 hypertensive patients attending th

Original Articles 2020-09-11

Is Community Intervention Effective for Improving Maternal, Newborn and Child Health Care in Hard-to-Reach Areas of Chin State, Myanmar?

To tackle the maternal, newborn and child health (MNCH) care needs is a challenging situation in remote and hard-to-reach areas. Intervention activities focusing on strengthening community health care network through community participation and supporting Basic Health Staffs for MNCH ser

Original Articles 2020-09-14

Incidence of Snakebite in Four Townships of Yangon Region

The true incidence of snakebite in Myanmar is unknown. The current data are based on hospital returns to Ministry of Health and Sports and they are likely to be under-reported. A community-based survey is useful to know the current burden of snakebite and thus for planning and formulating str

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Aims of MHSR Journal

• To serve as an important medium for the publication of original research in the field of medical science and health research, thus filling gaps in health knowledge for effective utilization of research findings
• To impart current medical knowledge and updated scientific information obtained from research to health professionals for better and appropriate health care management
• To disseminate recent basic, applied and social research findings among health personnel of different strata for enhancing worldwide health development

Archives   2006

Myanmar   Health   Sciences   Research   Journal

Volume   18,  Number   3

TITLE:   Molecular detection of primary dapsone resistant Mycobacterium leprae in Myanmar.
AUTHOR:   Khin Saw Aye; Yin Thet Nu Oo; Kyaw Kyaw; Masanori Matsuoka; Masanori Kai
SOURCE:   Myanmar Health Sciences Research Journal. 2006; 18(3): 122-127
ABSTRACT:   Currently recommended control measures for treating leprosy with multi-drug therapy (MDT) should control the spread of drug resistant strains; however, dapsone (DDS) resistance continues to be reported. Compre-hensive estimates of drug-resistant leprosy are difficult to obtain due to the cumbersome nature of the conventional drug susceptibility testing method using mouse footpad inoculation, which requires at least 6 months to obtain results. Recently, it has been determined that DDS resistant strain contains missing mutations in codon 53 and 55 of the fol P1 gene of Mycobacterium leprae, and definitive evidence linking these mutations with DDS resistance in M. leprae has been obtained. Based on these mutations, fol P1 gene contained these mutation points (hot spots) was amplified by polymerase chain reaction (PCR) and followed by sequencing to detect mutations. A total of 50 multibacillry leprosy cases before MDT treatment attending Central Special Skin Clinic, Yangon General Hospital were determinedfol P1 gene mutations. DDS resistance was detected in four cases (8%). This study is part of the detection of multi-drug resistant leprosy in Myanmar.
SUBJECT HEADINGS:   Mycobacterium leprae. Dapsone. Drug Resistance.
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