- To serve as an important medium for the publication of original research in the field of medical science and health research, thus filling gaps in health knowledge for effective utilization of research findings
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Archives 2006
Myanmar Health Sciences Research Journal
Volume 18, Number 3
TITLE: Use of risk scores for screening of hepatitis C of blood donors in remote areas.
AUTHOR: Myo Khin; Yi Yi Kyaw; Win Pa Pa Naing; Than Than Aye; Swe Zin Yu; San San Oo; Khine Win
SOURCE: Myanmar Health Sciences Research Journal. 2006; 18(3): 109-113
ABSTRACT: Hepatitis C virus (HCV) infection is considered as an emerging health problem in Myanmar. Seropositivity rates vary from 3% in blood donors at major blood banks in Yangon to over 10% in northeast and northwest border areas. Determination of HCV is limited in remote areas as it is expensive and some test systems need special equipment. To assist in the control of hepatitis C in Myanmar, we developed a simple system for screening of HCV infection using risk scores. The scores were based on the data obtained from HCV surveys carried out at the northeast and northwest border areas of Myanmar. The database consisted of 652 subjects (250 males, 402 females), aged 18 years to 60 years.Multivariate analyses revealed the following factors to be related to HCV infection in the subjects: more than 30 years of age, Odd Ratios (OR)=2.41 (p=0.001);a history of tattooing,OR= 1.78 (p=0.035); a history of hepatitis in the family, OR=1.58 (p=0.049). The screening scores for HCV infection were developed using risk scores. Validity was analyzed using the Receiver Operating Characteristics curve. The sensitivity of the system was 80% and the specificity 37% when a cut-off score of >2.5 was used. By increasing the cut-off score, higher specificity (up to 80%) could be achieved at the cost of decreasing sensitivity. The developed risk scores could be applied for screening of blood donors for HCV infection in areas where laboratory HCV testing could not be performed.
SUBJECT HEADINGS: Hepatitis C. Blood Donors.
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