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Aims of MHSR Journal

• To serve as an important medium for the publication of original research in the field of medical science and health research, thus filling gaps in health knowledge for effective utilization of research findings
• To impart current medical knowledge and updated scientific information obtained from research to health professionals for better and appropriate health care management
• To disseminate recent basic, applied and social research findings among health personnel of different strata for enhancing worldwide health development

Archives   2007

Myanmar   Health   Sciences   Research   Journal

Volume   19,  Number   3

TITLE:   Evaluation of in vitro antimicrobial susceptibility of Neisseria gonorrhoeae strains isolated from symptomatic men and women in Yangon.
AUTHOR:   Wah Wah Aung; Kyi Kyi Thinn
SOURCE:   Myanmar Health Sciences Research Journal. 2007; 19(3): 173-178
ABSTRACT:   The antimicrobial susceptibility pattern of Neisseria gonorrhoeae varies from one country to another and may also change with time. Periodic monitoring of the susceptibility of N. gonorrhoeae strains is important in order to adopt empirical treatment strategies. Antibiotic susceptibility of 40 N. gonorrhoeae strains isolated from urethral swab and endocervical swab specimens of symptomatic men and women was evaluated by disc diffusion method and determination of minimum inhibitory concentration (MIC) using E test method at Bacteriology Research Division, Department of Medical Research (Lower Myanmar) from August 2006 to July 2007. The susceptibility results of both methods showed satisfactory agreement for ciprofloxacin (kappa=0.646), ceftriazone (kappa=0.806) and penicillin (kappa=0.536). The tested N. gonorrhoeae isolates were susceptible to azithromycin (87.5%), cefixime (80%), ceftriaxone (>70%) and cipro-floxacin (55%) which are currently recommended drugs for gonococcal infections. High level ciprofloxacin resistance (MIC4 µg/ml) was found in 30% of tested isolates. The present study highlighted that majority of the tested N. gonorrhoeae isolates were susceptible to azithromycin, cefixime, ceftriaxone and the occurrence of high level ciprofloxacin resistant strains in the study population. Both disc diffusion and E test susceptibility testing methods gave reproducible results. Thus cost-effective and more feasible disc diffusion method could remain as the method of choice for routine diagnostic laboratories.
SUBJECT HEADINGS:   Neisseria gonorrhoeae.
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