Short Reports 2020-09-14

Identification of the Potential Radiation Risk of Indoor Radon in Old Buildings of Pabedan Township, Yangon Region

Original Articles 2020-09-14

Incidence of Snakebite in Four Townships of Yangon Region

The true incidence of snakebite in Myanmar is unknown. The current data are based on hospital returns to Ministry of Health and Sports and they are likely to be under-reported. A community-based survey is useful to know the current burden of snakebite and thus for planning and formulating str

Original Articles 2020-09-11

Is Community Intervention Effective for Improving Maternal, Newborn and Child Health Care in Hard-to-Reach Areas of Chin State, Myanmar?

To tackle the maternal, newborn and child health (MNCH) care needs is a challenging situation in remote and hard-to-reach areas. Intervention activities focusing on strengthening community health care network through community participation and supporting Basic Health Staffs for MNCH ser

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Aims of MHSR Journal

• To serve as an important medium for the publication of original research in the field of medical science and health research, thus filling gaps in health knowledge for effective utilization of research findings
• To impart current medical knowledge and updated scientific information obtained from research to health professionals for better and appropriate health care management
• To disseminate recent basic, applied and social research findings among health personnel of different strata for enhancing worldwide health development

Archives   2007

Myanmar   Health   Sciences   Research   Journal

Volume   19,  Number   3

TITLE:   Antimalarial activity and related chemical constituents of Swertia species from Kayah State.
AUTHOR:   Khin Phyu Phyu; Win Myint; Ye Htut; Mya Aye; Kyin Hla Aye; Ni Ni
SOURCE:   Myanmar Health Sciences Research Journal. 2007; 19(3): 131-135
ABSTRACT:   The most promising activity was found in ethanol extracts of Swertia purpurescens (whole plant) at the dosage of 2.8 g/kg/day both in suppressive and therapeutic tests when various extracts of these three plant specimens were preliminary screened for antimalarial activity, using in in vivo model. The active ethanol extract observed to have significant antimalarial activity in in vivo model was subjected to in vitro p. falciparum system. It’s antimalarial activity was found starting from the dosage of 1000 µg/ml. Chemical separation of the active extracts was serially carried out by means of solvent–solvent partition, column chromatographic and thin layer chromatographic techniques. Out of seven components yielded, only one showed to have suppressive activity against malaria parasite in both experimental models. The active compound was identified as a xanthone molecule by means of UV, FTIR, 1HNMR (600MHz), DQF-COSY, HSQC, HMBC and NOE spectroscopic techniques. Swertia chirata and xanthone molecules have known to be antimalarial agents in recent years. Therefore, this study could structurally elucidate an active compound Bellidifolin from S. purpurescens and for the first time, the possessing of antimalarial activity in S. purpurescens could be reported.
SUBJECT HEADINGS:   Antimalarials. Plants, Medicinal.
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