Myanmar Health Sciences Research Journal
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Aims of MHSR Journal
  • To serve as an important medium for the publication of original research in the field of medical science and health research, thus filling gaps in health knowledge for effective utilization of research findings
  • To impart current medical knowledge and updated scientific information obtained from research to health professionals for better and appropriate health care management
  • To disseminate recent basic, applied and social research findings among health personnel of different strata for enhancing worldwide health development


Archives   2007

Myanmar   Health   Sciences   Research   Journal

Volume   19,  Number   2

TITLE:   Detection of Glucose-6-phosphate dehydrogenase G6PD enzyme deficiency in the field for treatment of malaria.
AUTHOR:   Khin Lin; Aung Than; Mya Moe; Saw Lwin; Thein Tun
SOURCE:   Myanmar Health Sciences Research Journal. 2007; 19(2): 103-105
ABSTRACT:   Malaria is the first priority health problem in Myanmar and early diagnosis with prompt and effective treatment is essential for reduction of morbidity and mortality due to the disease. Primaquine is the only effective drug to prevent relapses of liver form of Plasmodium vivax and Plasmodium ovale and can also be used to kill gametocyte form of Plasmodium falciparum and Plasmodium malariae. Primaquine can cause haemolysis in glucose-6¬phosphate dehydrogenase G6PD deficient individual and prevalence of G6PD deficiency varies among different ethnic races. Malaria survey was done during 2001-2003 in Mon and Shan States and prevalence of G6PD deficiency was investigated by rapid screening method of Hirono using DEAE (Di-Ethyl Amine-Ethylene) and Sephadex mixture. In normal person the test shows orange ring due to the presence of G6PD enzyme which is absent in G6PD deficient person. Among 1079 samples tested, 47 (4.5%) was found to have severe type of G6PD deficiency by the test. In relation to the ethnic region, G6PD deficiency rate was 5.5% (29/338) among Burmese, 3.2% (6/191) among Chinese, 3.4% (5/146) among Indians, 3.3% (3/92) among Mons, 5.1% (3/59) among Shans and 6.7% (1/15) among Kayin races. This rapid test can detect severe G6PD deficiency in the field, thus primaquine can be prescribed safely to malaria patients.
SUBJECT HEADINGS:   Glucosephosphate Dehydrogenase. Malaria.
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Vision : Achieving a healthier nation through application of research findings          Mission Statement : To Develop and promote solutions to the major health problems of Myanmar