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Aims of MHSR Journal

• To serve as an important medium for the publication of original research in the field of medical science and health research, thus filling gaps in health knowledge for effective utilization of research findings
• To impart current medical knowledge and updated scientific information obtained from research to health professionals for better and appropriate health care management
• To disseminate recent basic, applied and social research findings among health personnel of different strata for enhancing worldwide health development

Archives   2007

Myanmar   Health   Sciences   Research   Journal

Volume   19,  Number   2

TITLE:   Anithypertsensive effect of Plantago major Linn. whole plant (Ahkyawpaung-tahtaung) on mild to moderate hypertensive patients.
AUTHOR:   Tin May Nyunt; Khine Khine Lwin; Than Than Aye; May Aye Than; Khin Chit; Thein Kyaw; Ohnmar May Tin Hlaing; Min Wun; Nu Nu Aye
SOURCE:   Myanmar Health Sciences Research Journal. 2007; 19(2): 97-102
ABSTRACT:   A clinical trial to determine the antihypertensive effect of medicinal plant, Plantago major Linn.(Ahkyawpaung-tahtaung) (whole plant) crude powder tablet was carried outon 10 mild to moderate hypertensive patients attending theout patient department (OPD) of Thingungyun Sanpya Hospital, Yangon and Traditional Medicine Hospital, Yangon. After washout period of 3 days, patients were treated orally with Plantago major Linn. whole plant crude powder tablet 3 g three times daily for 12 weeks. Blood pressure was monitored at 0 hr, 0.5hr, 1hr, 2 hr, 3 hr after first dose of trial drug. Monitoring of blood pressure and vital signswere done on day 1, day 2, day 3 and weekly up to 12 weeks. Laboratory investigations such as blood for complete picture, platelet count, random blood sugar level, liver function test, renal function test and ECG were done before and after the study. The results showed that reduction of blood pressure from baseline level was found at (0.5 hr-1 hr) after the first dose of the trial drug and was maintained up to 3 hr post dose. After 12 weeks of treatment with this trial drug,itwasobservedthatsignificant reduction of mean blood pressurewas from 150 ± 2.58/98 ± 1.33 mmHg (baseline blood pressure) to 129 ± 2.77/86 ± 1.63 mmHg (P<0.001). This trial drug decreased the mean systolic blood pressure and diastolic blood pressure from baseline level by 21 mmHg (p<0.001) and 12 mmHg (p<0.001) respectively. No side effects were observed. Therefore, it can be concluded that Plantago major Linn. showed significant antihypertensive effect on mild to moderate hypertensive patients with no sideeffects.
SUBJECT HEADINGS:   Plantago. Hypertension. Antihypertensive Agents. Plants, Medicinal.
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