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The true incidence of snakebite in Myanmar is unknown. The current data are based on hospital returns to Ministry of Health and Sports and they are likely to be under-reported. A community-based survey is useful to know the current burden of snakebite and thus for planning and formulating str

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Aims of MHSR Journal

• To serve as an important medium for the publication of original research in the field of medical science and health research, thus filling gaps in health knowledge for effective utilization of research findings
• To impart current medical knowledge and updated scientific information obtained from research to health professionals for better and appropriate health care management
• To disseminate recent basic, applied and social research findings among health personnel of different strata for enhancing worldwide health development

Archives   2007

Myanmar   Health   Sciences   Research   Journal

Volume   19,  Number   2

TITLE:   Comparison of efficacy and safety of different brands of oral artesunateplus mefloquine in uncomplicated falciparum malaria in adults.
AUTHOR:   Khin Phyu Pyar; Win Win Myint; Myat Phone Kyaw; Thaw Zin; Khin Nyo; Than Htut; Malar Than
SOURCE:   Myanmar Health Sciences Research Journal. 2007; 19(2): 63-68
ABSTRACT:   The efficacy of artemisinin derivatives in treatment of falciparum malaria is well established and a variety of different brands are now available, assumingly to be identical in composition and efficacy. A hospital-based, double blind randomized, controlled study to find out the efficacy and pharmacokinetics of different brands of artesunate when combined with mefloquine in Myanmar population was carried out in CRU (Malaria) DSGH, to establish the relative merits of the different brands, provide data for consumer choice and for better future utilization of these combinations in the chemotherapy of malaria. A total of 120 adult uncomplicated falciparum malaria patients were randomized, to receive 4 different brands of artesunate 200 mg OD for 3 days. A single brand of mefloquine (Helm-Germany) 500 mg OD for 3 days was used as the combination drug in all four regimens. Artequin TM600/1500 combi-pack (Mepha-Switzerland) was used as the control drug. The Mean Fever Clearance Times (FCT) were 11.15 hrs, 13.69 hrs, 11.8 hrs, 11.68 hrs and 12.88 hrs. The Mean Parasite Clearance Times (PCT) were 46.12 hrs, 50.51 hrs, 46.88 hrs, 42.45 hrs and 51.22 hrs in the Plasmotrim LactabTM 200 mg (Mepha-Switzerland), Falcinate Tab 50 mg (Aurocham-India), Dawnasunate Tab 50 mg (MPF, Myanmar), Artenmed Tab 50 mg (Vietnam) and Control drug. Artequin TM600/1500 combi-pack (Mepha-Switzerland) respectively. The 14 days Adequate Clinical and Parasitological Response (ACPR) was 100% in all the five groups. There were no adverse, clinical, hematological, biochemical and ECG changes in all the groups. The different brands of artesunate available are comparable in efficacy for the treatment of uncomplicated falciparum malaria in adults.
SUBJECT HEADINGS:   Mefloquine. Malaria, Falciparum.
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