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Is Community Intervention Effective for Improving Maternal, Newborn and Child Health Care in Hard-to-Reach Areas of Chin State, Myanmar?

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Incidence of Snakebite in Four Townships of Yangon Region

The true incidence of snakebite in Myanmar is unknown. The current data are based on hospital returns to Ministry of Health and Sports and they are likely to be under-reported. A community-based survey is useful to know the current burden of snakebite and thus for planning and formulating str

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Aims of MHSR Journal

• To serve as an important medium for the publication of original research in the field of medical science and health research, thus filling gaps in health knowledge for effective utilization of research findings
• To impart current medical knowledge and updated scientific information obtained from research to health professionals for better and appropriate health care management
• To disseminate recent basic, applied and social research findings among health personnel of different strata for enhancing worldwide health development

Archives   2007

Myanmar   Health   Sciences   Research   Journal

Volume   19,  Number   1

TITLE:   Production of Russell's viper (Daboia russelii siamensis) antivenom in laying hens.
AUTHOR:   Aye Aye Myint; Tun Pe
SOURCE:   Myanmar Health Sciences Research Journal. 2007; 19(1): 37-42
ABSTRACT:   Traditional antivenoms raised in horses carry complement-mediated side effects, serum sickness and occasional anaphylactic shock. In order to circumvent these side effects and to supplement antivenom production, it was attempted to induce Russell’s viper (Doboia russelii siamensis) antivenom in laying hens. Three injections of Russell’s viper venom, a total of (500µg per hen) given at 4 week intervals yielded 1.85 gm specific chicken immunoglobulin IgY per month which is equivalent to total IgG obtained from 8 rabbits or two goats per month. The IgY antibody extracted from egg yolk with polyethylene glycol 6000 could withstand 2LD50 dose of the immunizing venom (ED50 =29.7µl/mouse). Antibody IgY level in egg yolk was determined by indirect enzyme immunoassay method and specificity of the antibody was checked by immunodiffusion.The antibody could be detected as early as 2 weeks after the first immunization and peak antibody levels were maintained up to 20 weeks before declining to a low level. The major advantages of the avian antivenom are the eggs from immunized hens provide a continual source of antibody, it is inexpensive to keep hens as laboratory animals and require only 3 injections using minute amounts of the venom (500µg/hen). The study highlighted that antivenom of interest could be raised by using this simple technique and the avian Russell’s viper antivenom could be used for treating Russell’s viper bite cases as well as to supplement antivenom production of the country.
SUBJECT HEADINGS:   Russell's Viper. Antivenins. Eggs.
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