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Archives 2008
Myanmar Health Sciences Research Journal
Volume 20, Number 2
TITLE: Hypocholesterolaemic potential of Russell's viper (Daboia russelii siamensis) venom in experimental mice.
AUTHOR: Win Aung; Shwe Zin Lin; Khin Maung Maung
SOURCE: Myanmar Health Sciences Research Journal. 2008; 20(2): 119-124
ABSTRACT: With an aim to determine the hypocholesterolaemic potential of Russell's viper venom (RVV), changes in serum cholesterol levels of experimental mice, envenomed with different dosages of RVV were studied at various time intervals after envenomation, and were compared with changes in serum total protein and albumin. This in vivo study demonstrated that the serum cholesterol levels in these mice significantly reduced at half an hour after administration of RVV, obtaining its lowest level at one hour after envenomation. Although the degree of hypocholesterolaemia did not directly associate with respective dosage of RVV administered, the rates of fall in serum cholesterol level within first 24 hours were found to be apparently correlated with the relapsing time intervals after envenomation. Besides, RVV was found to have a direct lowering action on serum cholesterol in in vitro test. It could be concluded that the development of hypocholesterolaemia in experimental mice at early hours after adminis-tration of RVV indicates the sign of envenomation, and RVV also seems to be promising in cholesterol lowering action which could be used as a diagnosticindicator of envenomation.
SUBJECT HEADINGS: Russell's Viper. Viper Venoms.
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