Myanmar Health Sciences Research Journal
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Aims of MHSR Journal
  • To serve as an important medium for the publication of original research in the field of medical science and health research, thus filling gaps in health knowledge for effective utilization of research findings
  • To impart current medical knowledge and updated scientific information obtained from research to health professionals for better and appropriate health care management
  • To disseminate recent basic, applied and social research findings among health personnel of different strata for enhancing worldwide health development


Archives   2008

Myanmar   Health   Sciences   Research   Journal

Volume   20,  Number   2

TITLE:   Hypocholesterolaemic potential of Russell's viper (Daboia russelii siamensis) venom in experimental mice.
AUTHOR:   Win Aung; Shwe Zin Lin; Khin Maung Maung
SOURCE:   Myanmar Health Sciences Research Journal. 2008; 20(2): 119-124
ABSTRACT:   With an aim to determine the hypocholesterolaemic potential of Russell's viper venom (RVV), changes in serum cholesterol levels of experimental mice, envenomed with different dosages of RVV were studied at various time intervals after envenomation, and were compared with changes in serum total protein and albumin. This in vivo study demonstrated that the serum cholesterol levels in these mice significantly reduced at half an hour after administration of RVV, obtaining its lowest level at one hour after envenomation. Although the degree of hypocholesterolaemia did not directly associate with respective dosage of RVV administered, the rates of fall in serum cholesterol level within first 24 hours were found to be apparently correlated with the relapsing time intervals after envenomation. Besides, RVV was found to have a direct lowering action on serum cholesterol in in vitro test. It could be concluded that the development of hypocholesterolaemia in experimental mice at early hours after adminis-tration of RVV indicates the sign of envenomation, and RVV also seems to be promising in cholesterol lowering action which could be used as a diagnosticindicator of envenomation.
SUBJECT HEADINGS:   Russell's Viper. Viper Venoms.
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Vision : Achieving a healthier nation through application of research findings          Mission Statement : To Develop and promote solutions to the major health problems of Myanmar