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Aims of MHSR Journal

• To serve as an important medium for the publication of original research in the field of medical science and health research, thus filling gaps in health knowledge for effective utilization of research findings
• To impart current medical knowledge and updated scientific information obtained from research to health professionals for better and appropriate health care management
• To disseminate recent basic, applied and social research findings among health personnel of different strata for enhancing worldwide health development

Archives   2008

Myanmar   Health   Sciences   Research   Journal

Volume   20,  Number   2

TITLE:   Hypoglycemic effect of Curcuma Comosa Roxb. (Nanwin-Ga) rhizomes on rabbits Model.
AUTHOR:   Khine Khine Lwin; Mu Mu Sein Myint; May Aye Than; Khin Tar Yar Myint; Win Win Maw; San San Myint; Myint Myint Khine; Nu Nu Win; Hla Phyo Lin
SOURCE:   Myanmar Health Sciences Research Journal. 2008; 20(2): 107-113
ABSTRACT:   This study was carried out to determine the phytochemical constituents, acute toxicity and hypoglycemic effect of crude powder and 80% ethanolic extract of dried rhizomes of Curcuma comosa Roxb. (Nanwin-ga). Adrenaline-induced hyperglycemic rabbits were used to study the hypo-glycemic effect. Oral route of administration was used in this study. The phytochemical studies of the crude powder and 80% ethanolic extract of this plant showed that both contained alkaloids, flavonoids, glycosides, steroids, saponins, tannins and amino acid. In acute toxicity study in mice, it was observed that the crude powder of the rhizomes was not toxic up to the maximal feasible dose of 5g/kg. But, 80% ethanolic extract of the dried rhizomes showed mild acute toxic effect and median lethal dose (LD50) was determined to be 5.2 g/kg and its confident limit was 4 g/kg - 6.76 g/kg. The results showed that the 80% ethanolic extract of the rhizomes at the dose level of 1.5 g/kg had significant hypoglycemic effect at 2 hr, 3hr and 4 hr (p<0.01- p<0.05) after oral administration when compared with those of the controls. But, the crude powder of the rhizomes at the dose level of 3 g/kg showed no significant hypoglycemic effect. It was observed that the hypoglycemic effect of 80% ethanolic extract was inferior to that of the standard drug glibenclamide. Therefore, it can be concluded that the 80% ethanolic extract of the dried rhizomes of Curcuma comosa Roxb. (Nanwin-ga) possessed significant hypoglycemic effect on adrenaline-induced hyperglycemic rabbits model and the effect was inferior to that of glibenclamide.
SUBJECT HEADINGS:   Hypoglycemic Agents. Plants, Medicinal.
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