Original Articles 2012-02-20

The Use of Herbal Medicine and Traditional Medicine Formulations (TMFs) for Hypertension at Traditional Medicine Hospital, Yangon

This study was done to determine the use of herbal medicines and Traditional Medicine Formulations (TMFs) for treating hypertension at Outpatients' Department (OPD) of Traditional Medicine Hospital, Yangon. This study was a cross-sectional, descriptive study in 140 hypertensive patients attending th

Original Articles 2020-09-11

Is Community Intervention Effective for Improving Maternal, Newborn and Child Health Care in Hard-to-Reach Areas of Chin State, Myanmar?

To tackle the maternal, newborn and child health (MNCH) care needs is a challenging situation in remote and hard-to-reach areas. Intervention activities focusing on strengthening community health care network through community participation and supporting Basic Health Staffs for MNCH ser

Original Articles 2020-09-14

Incidence of Snakebite in Four Townships of Yangon Region

The true incidence of snakebite in Myanmar is unknown. The current data are based on hospital returns to Ministry of Health and Sports and they are likely to be under-reported. A community-based survey is useful to know the current burden of snakebite and thus for planning and formulating str

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Aims of MHSR Journal

• To serve as an important medium for the publication of original research in the field of medical science and health research, thus filling gaps in health knowledge for effective utilization of research findings
• To impart current medical knowledge and updated scientific information obtained from research to health professionals for better and appropriate health care management
• To disseminate recent basic, applied and social research findings among health personnel of different strata for enhancing worldwide health development

Archives   2008

Myanmar   Health   Sciences   Research   Journal

Volume   20,  Number   2

TITLE:   Immunohistopathology of liver in autopsy cases of dengue shock syndrome
AUTHOR:   Khin Saw Aye; Ne Win; Kyaw Zin Wai; Kyaw Moe; Sanya Sukpanichnant, Prida Malasit; Scott B Halsted
SOURCE:   Myanmar Health Sciences Research Journal. 2008; 20(2): 95-100
ABSTRACT:   Dengue hemorrhagic fever (DHF) is a severe febrile disease, characterized by abnormalities in hemostasis and increased vascular permeability, which in some cases results in hypovolemic shock and in dengue shock syndrome. The clinical features of DHF include plasma leakage, bleeding tendency and liver involvement such as enlargement of the liver. During the peak period of outbreak from July through October, of 2005 and 2006, a total of 13 fatal cases of dengue hemorrhagic fever (DHF)/ dengue shock syndrome (DSS) were collected from Intensive Care Unit, Yangon Children Hospital to study their immunohistopathology of DHF. The liver seems to be a target for dengue virus, so postmortem examinations were performed to investigate histopathological changes and whether the virus and viral antigens were present in target cells of the liver. We detected Kupffer cell hyperplasia in 100%, hemorrhage in 92%, mixed midzonal and centrilobular necrosis in 85%, and hemophagocytosis in 77% by using hematoxylin and eosin stain of routine histopathological standard method. Dengue virus antigens of the structural (envelop) and non-structural (NS1) proteins were detected in 54% and 77% respectively in both hepatocytes and Kupffer cells, using immunohistochemistry. There was no recruitment of polymorphonuclear cells; however, minimal degree of portal infiltration by lymphocytes was detected in the liver lesions of patients who died from DHF. Thus, our findings conclude that the hepatocytes and Kupffer cells may be target cells supporting virus localization and replication to provide more information for understanding the pathogenesis of liver involvement in DHF.
SUBJECT HEADINGS:   Autopsy. Dengue Hemorrhagic Fever.
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