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Aims of MHSR Journal

• To serve as an important medium for the publication of original research in the field of medical science and health research, thus filling gaps in health knowledge for effective utilization of research findings
• To impart current medical knowledge and updated scientific information obtained from research to health professionals for better and appropriate health care management
• To disseminate recent basic, applied and social research findings among health personnel of different strata for enhancing worldwide health development

Archives   2008

Myanmar   Health   Sciences   Research   Journal

Volume   20,  Number   2

TITLE:   Hypoglycemic activities of ethanolic Gynura procumbens leaves extrants in rats.
AUTHOR:   Cho Cho Thet; Moe Moe Tun; Thein Tun; Maung Maung; Phyo Mon Oo; Than Tun
SOURCE:   Myanmar Health Sciences Research Journal. 2008; 20(2): 85-88
ABSTRACT:   Traditional medicinal plants including those with anti-hyperglycemic effect have been widely used in Myanmar. Indeed, hundreds of plants were used traditionally for management and/or control of both insulin-dependent (IDDM) and non-insulin-dependent (NIDDM) diabetes mellitus worldwide. There was no recorded evidence of Gynura procumbens leave for its anti-hyperglycemic effect in Myanmar. The present study aimed to evaluate the anti-hyperglycemic potential of G. procumbens leaves on adrenaline-induced hyperglycemic rats. It was a preclinical animal model, conducted during May, 2007 in DMR (Upper Myanmar). The extracts (different doses), glibenclamide and water were administered orally to different groups of adrenaline-induced hyperglycemic albino rats of both sexes (7 rats in each group). Oral administration of G.procumbens ethanol extracts (150 and 300 mg/kg) showed hypoglycemic effect in adrenaline-induced hyper-glycemic rats. The efficacy was comparable with glibenclamide (0.5mg/ kg).G. procumbens ethanol extract (300 mg/kg orally) significantly inhibited hyperglycemia induced by adrenaline (0.2 ml/kg). G procumbens leaves extract with the dosage of 300 mg/kg was more potent than glibenclamide at the first 2 hours (1 hour and 2 hour) (P value = 0.0484, 0.0035), respectively. However, in 3 hour and 4 hour, there was no significant differences in tested extract and glibenclamide (P value = 0.4864, 0.4256), respectively. The results indicated that the ethanol extract of G. procumbens leaves possess anti-hyperglycemic activity.
SUBJECT HEADINGS:   Hypoglycemic Agents. Ethanol. Plants, Medicinal.
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