Myanmar Health Sciences Research Journal
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Aims of MHSR Journal
  • To serve as an important medium for the publication of original research in the field of medical science and health research, thus filling gaps in health knowledge for effective utilization of research findings
  • To impart current medical knowledge and updated scientific information obtained from research to health professionals for better and appropriate health care management
  • To disseminate recent basic, applied and social research findings among health personnel of different strata for enhancing worldwide health development


Archives   2008

Myanmar   Health   Sciences   Research   Journal

Volume   20,  Number   1

TITLE:   Analysis of Hepatitis C Virus isolates from Tamu Township and identification of a new subtype of genotype 6.
AUTHOR:   Aye Aye Lwin; Khin May Oo; Myo Khin; Ne Win; Yi Yi Kyaw; Toshiyuki Shinji; Norio Koide; Shigeru Okada
SOURCE:   Myanmar Health Sciences Research Journal. 2008; 20(1): 39-45
ABSTRACT:   Genotyping of hepatitis C virus (HCV) is important for designing thera-peutic strategies and there is little information on the distribution of HCV genotypes in Myanmar. To determine the distribution of genotype/ subtype of HCV isolates from Tamu Township, a total of 501 blood samples were collected and tested for anti-HCV antibody by using the Ortho HCV Ab-PA test II kit. Genotyping was carried out by using reverse-transcriptase polymerase chain reaction (RT-PCR), direct DNA-sequencing and phylo-genetic analysis of the partial core sequences. Sixty-four (12.8%) samples were anti-HCV positive and 59 (92.1%) HCV isolates could be genotyped. Genetic characterization of viral sequences indicated that there are three major genotypes (6, 3 &1) and six minor subtypes as 1a (1.7%), 1b (15.3%), 3b (25.4%), 6m (3.4%), 6n (52.5%) and a new 6 subtype (1.7%). This study showed that HCV genotype distribution in Tamu Township has a distinct geographic variation from other South-East Asia countries in terms of the existence of the new genotype 6 subtype.
SUBJECT HEADINGS:   Hepacivirus. Genotype.
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Vision : Achieving a healthier nation through application of research findings          Mission Statement : To Develop and promote solutions to the major health problems of Myanmar