Myanmar Health Sciences Research Journal
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Aims of MHSR Journal
  • To serve as an important medium for the publication of original research in the field of medical science and health research, thus filling gaps in health knowledge for effective utilization of research findings
  • To impart current medical knowledge and updated scientific information obtained from research to health professionals for better and appropriate health care management
  • To disseminate recent basic, applied and social research findings among health personnel of different strata for enhancing worldwide health development


Archives   2009

Myanmar   Health   Sciences   Research   Journal

Volume   21,  Number   3

TITLE:   Sensitivity and specificity of parasite lactate dehydrogenase (PLDH) based rapid diagnostic test (SD Bioline malaria antigen test) in comparison with parasite density.
AUTHOR:   Khin Myo Aye; Myat Phone Kyaw; Tin Oo; Kyin Hla Aye; Cho Cho Win; Cho Cho
SOURCE:   Myanmar Health Sciences Research Journal. 2009; 21(3): 164-170
ABSTRACT:   A cross-sectional hospital-based study (Thanbyuzayat Township Hospital, Mon State) on 103 patients, who were tested with malaria microscopy and parasite lactate dehydrogenase (pLDH)-based rapid diagnostic test strips (RDTs) during 2008. The blood film results indicated that 84 (81.55%) patients were malaria parasite positive and 19 (18.45%) were malaria negative. Forty-two cases diagnosed as P. falciparum by RDT were diagnosed by microscopy as 35 cases of P.falciparum, 2 cases of P. malariae, one case of P.falciparum and P. malariae mixed infection, and4 cases of P.falciparum and P. vivax mixed infection. Forty-one patients diagnosed as non P. falciparum (Plasmodium species other than P. falciparum) by RDT were diagnosed by microscopy as 39 cases of P. vivax and 2 cases of mixed infection (P.falciparum and P. vivax). Twenty cases diagnosed as negative by RDT comprised of nineteen as negative and one as P. vivax by microscopy. The sensitivity was 100% and 97%, specificity was 90% and 96%, positive predictive value was 83% and 95% and negative predictive value was 100% and 98% for P.falciparum and non P.falciparum, respectively. The lowest parasite density detected by test was 109.5 parasites/μl for P. falciparum and 160 parasites/μl for P. vivax. In this study, the band intensity was significantly related to parasite density and the differences between mean parasite count was significant between faint and intermediate, intermediate and strong. Thus, it can generally estimate the parasite count and can be used in the field for screening of malaria parasite for preparation of quality control sample.
SUBJECT HEADINGS:   Oxidoreductases. Parasites. Malaria.
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Vision : Achieving a healthier nation through application of research findings          Mission Statement : To Develop and promote solutions to the major health problems of Myanmar