Myanmar Health Sciences Research Journal
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Aims of MHSR Journal
  • To serve as an important medium for the publication of original research in the field of medical science and health research, thus filling gaps in health knowledge for effective utilization of research findings
  • To impart current medical knowledge and updated scientific information obtained from research to health professionals for better and appropriate health care management
  • To disseminate recent basic, applied and social research findings among health personnel of different strata for enhancing worldwide health development


Archives   2009

Myanmar   Health   Sciences   Research   Journal

Volume   21,  Number   2

TITLE:   Characterization of Neisseria gonorrhoeae strains isolated from patients attending the Sexually Transmitted Diseases (STD) and gynaecology clinics in Yangon.
AUTHOR:   Wah Wah Aung; Kyi Kyi Thinn
SOURCE:   Myanmar Health Sciences Research Journal. 2009; 21(2):110-116
ABSTRACT:   A total of 42 N. gonorrhoeae strains were isolated from 200 patients (76 men and 124 women) attending STD and gynaecology clinics in Yangon during 2006 to 2008. All the strains belonged to WI serogroup. On the basis of plasmid-mediated antimicrobial resistance, they were characterized into 14 (33.3%) penicillinase producing N. gonorrhoeae (PPNG) strains, 6 (14.3%) tetracycline resistant N. gonorrhoeae (TRNG) strains, 10 (23.9%) PP/TRNG strains and 12 (28.6%) quinolone resistant N. gonorrhoeae (QRNG) strains. The plasmid profiles revealed as all PPNG isolates carried a 4.4 MDa penicillinase plasmid and 3 PP/TRNG isolates carried both 4.4 MDa penicillinase plasmid and 2.6 MDa cryptic plasmid. The majority of the N. gonorrhoeae isolates were susceptible to azithromycin, cefixime, ceftriaxone and spectinomycin. High-level ciprofloxacin resistant strains (ciprofloxacin minimum inhibitory concentration 4 µg/ml) and strains possessing multidrug resistance to first-line antibiotics, prescribed in the WHO recommended treatment regimen for gonorrhoea, were found among the tested isolates. Precise characterization of Myanmar gonococcal isolates provides benefits for the management and control of gonococcal infection and also elucidates the molecular epidemiology of gonorrhoea to some extent in Myanmar.
SUBJECT HEADINGS:   Neisseria gonorrhoeae. Sexually Transmitted Diseases.
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Vision : Achieving a healthier nation through application of research findings          Mission Statement : To Develop and promote solutions to the major health problems of Myanmar