Original Articles 2012-02-20

The Use of Herbal Medicine and Traditional Medicine Formulations (TMFs) for Hypertension at Traditional Medicine Hospital, Yangon

This study was done to determine the use of herbal medicines and Traditional Medicine Formulations (TMFs) for treating hypertension at Outpatients' Department (OPD) of Traditional Medicine Hospital, Yangon. This study was a cross-sectional, descriptive study in 140 hypertensive patients attending th

Original Articles 2020-09-11

Is Community Intervention Effective for Improving Maternal, Newborn and Child Health Care in Hard-to-Reach Areas of Chin State, Myanmar?

To tackle the maternal, newborn and child health (MNCH) care needs is a challenging situation in remote and hard-to-reach areas. Intervention activities focusing on strengthening community health care network through community participation and supporting Basic Health Staffs for MNCH ser

Original Articles 2020-09-14

Incidence of Snakebite in Four Townships of Yangon Region

The true incidence of snakebite in Myanmar is unknown. The current data are based on hospital returns to Ministry of Health and Sports and they are likely to be under-reported. A community-based survey is useful to know the current burden of snakebite and thus for planning and formulating str

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Aims of MHSR Journal

• To serve as an important medium for the publication of original research in the field of medical science and health research, thus filling gaps in health knowledge for effective utilization of research findings
• To impart current medical knowledge and updated scientific information obtained from research to health professionals for better and appropriate health care management
• To disseminate recent basic, applied and social research findings among health personnel of different strata for enhancing worldwide health development

Archives   2009

Myanmar   Health   Sciences   Research   Journal

Volume   21,  Number   1

TITLE:   Preliminary study on hypoglycemic effect of Phyllanthus Niruri Linn. (Taung-Ze-Phyu) on rabbit model.
AUTHOR:   Mu Mu Sein Myint; May Aye Than; Khine Khine Lwin; Aye Than; Khin Tar Yar Myint; Mar Mar Myint; Phyu Phyu Win; Hla Phyo Lin; Khin May Nyo
SOURCE:   Myanmar Health Sciences Research Journal. 2009; 21(1): 17-21
ABSTRACT:   The aim of this study is to determine phytochemical constituents, acute toxicity and the hypoglycemic effect of aqueous and 95% ethanol extract of whole plant of Phyllanthus niruri Linn. (Taung-ze-phyu). Phytochemical results showed that crude powder, aqueous extract and 95% ethanol extract contained alkaloids, flavonoids, tannins, saponins, steroids, amino acids and polyphenols. Acute toxicity study of crude powder, aqueous extract and 95% ethanol extract were evaluated in mice. Both crude powder and 95% ethanol extract showed no evidence of toxicity up to the maximum feasible dose level of 3 gm/kg body weight. In contrast, the maximum feasible dose level of aqueous extract was 6 g/kg body weight. Therefore, the median lethal dose (LD50) of crude powder and 95% ethanol extract was observed to be more than 3 gm/kg body weight. The median lethal dose (LD50) of aqueous extract was observed to be more than 6 gm/kg body weight. Evaluation of hypoglycemic effect of 95% ethanol extract (1.5 gm/kg body weight) and aqueous extract (3 gm/kg body weight) was carried out on adrenaline-induced diabetic rabbits. It was found that 95% ethanol extract significantly lowered the blood glucose levels at 2hr (p<0.05). Aqueous extract also lowered the blood glucose level at 1hr, 2hr, 3hr and 4hr (p<0.005 ~ p<0.05) respectively when compared with those of the control. Hypoglycemic effect of standard drug glibenclamide (4 gm/kg body weight) was also studied to compare with that of the plant extracts. Between the two extracts, the effect of aqueous extract (3 gm/kg body weight) when compared with that of glibenclamide was not significantly different.
SUBJECT HEADINGS:   Medicine, Traditional. Plants, Medicinal. Hypoglycemic Agents.
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