Myanmar Health Sciences Research Journal
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Aims of MHSR Journal
  • To serve as an important medium for the publication of original research in the field of medical science and health research, thus filling gaps in health knowledge for effective utilization of research findings
  • To impart current medical knowledge and updated scientific information obtained from research to health professionals for better and appropriate health care management
  • To disseminate recent basic, applied and social research findings among health personnel of different strata for enhancing worldwide health development

Archives   2014

Myanmar   Health   Sciences   Research   Journal

Volume   26,  Number   1

TITLE:   Nephroprotective Effect of Water Extract of Alternanthera pungens (Myae-Khat-Khet-mauk) in Albino Rats Using Cisplatin-induced Acuted Renal Failure
AUTHOR:   Khin Phyu Phyu, Lei Lei Win, Khin Mi Mi Lay, Kyawt Kyawt Khaing, Kyi San, Aung Thuya, Win Khaing; Kyaw Zin Thant
SOURCE:   Myanmar Health Sciences Research Journal. 2014; 26(1):35-40
ABSTRACT:   The present study was conducted to investigate the possible potential nephroprotcctive activity of watery extract or whole plant or Alternanthera. Pungens in cisplatin-induced nephrotoxic rats. Nephrotoxicity was induced in Wistar strain albino rats by single intraperitoneal (i.p) administration of cisplatin 5 mg/kg (n=6). Effect of concurrent administration or Alternan-thera pungens watery extract at the doses of 800 mg/kg, 1.600 mg/kg and 3,200 mg/kg body weight (n=o in each group), given by oral route was determined using serum creatinine, serum urea and change in body weight as indicators of kidney damage. Cystone, polyherbal renal protective drug. Was used as standard drug for nephroprotcctive activity. At the dosages of 1,600 mg/kg and 3,200 mg/kg body weight of the watery extract of Alternanthera pungens showed significant decrease in elevated serum urea and creatinine (p<0.00 1) (one-way ANOVA, followed by Dunnetts test) when compared to that of toxic group. Both groups showed significant protective activity in cisplatin-induced nephrotoxic rats. At the dose of 1,600 mg/kg watery extract and cystone standard were found to normalize the serum urea and creatinine levels when compared to normal control. It was observed that the watery extract of Alternanthera pungens significantly protected the kidneys from injury. The current study revealed that the watery extract of Alternanthera pungens had promising nephro- protective activity and was comparable to cystone in the animal model.
SUBJECT HEADINGS:   Acute Kidney Injury. Plants, Medicinal

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Vision : Achieving a healthier nation through application of research findings          Mission Statement : To Develop and promote solutions to the major health problems of Myanmar