- To serve as an important medium for the publication of original research in the field of medical science and health research, thus filling gaps in health knowledge for effective utilization of research findings
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Archives 2014
Myanmar Health Sciences Research Journal
Volume 26, Number 1
TITLE: Anti-diarrhoeal Effect of Ethanolic Extract of Cuminum cyminum Linn. On Cast Oil-included Diarrhoea in Mice Model
AUTHOR: Aung Aung Maw; May Aye Than; Mu Mu Sein Myint; Khin Tar Yar Myint; Win Win Maw; Thandar Myint; Nu Nu Win; Ei Ei Soe
SOURCE: Myanmar Health Sciences Research Journal. 2014; 26(1):6-10
ABSTRACT: This study was to determine phytochemical constituents, acute toxicity and anti-diarrhoeal activity of 80% cthanolic extract of cumin seeds. The phytochemical tests showed alkaloids, llavonoids, glycosides, tannins, steroids, phenols, saponins, and amino acids were present in the extract whereas resins, triterpine and cyanogenic glycoside were not. Acute toxicity test of the 80% ethanolic extract of cumin seeds showed no toxicity in albino mice, even with maximum permissible dose of 16 g/kg body weight. Antidiarrhoeal activity was evaluated by castor oil-induced diarrhoeal test, cnteropooling test and intestinal transit test on mice. Three doses (3, 6 and 9 g/kg body weight) of tested extracts showed significant antidiarrhoeal effect (% inhibition or defecation) (p<0.0 1) when compared to control. The extracts of 6 g/kg, 9 g/kg and loperamide showed a significant decrease in the onset of defecation (p<0.05) when compared to control. All doses of tested extracts showed anti-diarrhoeal effects comparable to loperamide (6 mg/kg) as seen by a marked decrease in the number or diarrhoeal stools, from 2 1.1 7
SUBJECT HEADINGS: Antidiarrheals. Plant Extract. Castor Oil
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