Myanmar Health Sciences Research Journal
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Aims of MHSR Journal
  • To serve as an important medium for the publication of original research in the field of medical science and health research, thus filling gaps in health knowledge for effective utilization of research findings
  • To impart current medical knowledge and updated scientific information obtained from research to health professionals for better and appropriate health care management
  • To disseminate recent basic, applied and social research findings among health personnel of different strata for enhancing worldwide health development

Archives   2014

Myanmar   Health   Sciences   Research   Journal

Volume   26,  Number   1

TITLE:   Anti-diarrhoeal Effect of Ethanolic Extract of Cuminum cyminum Linn. On Cast Oil-included Diarrhoea in Mice Model
AUTHOR:   Aung Aung Maw; May Aye Than; Mu Mu Sein Myint; Khin Tar Yar Myint; Win Win Maw; Thandar Myint; Nu Nu Win; Ei Ei Soe
SOURCE:   Myanmar Health Sciences Research Journal. 2014; 26(1):6-10
ABSTRACT:   This study was to determine phytochemical constituents, acute toxicity and anti-diarrhoeal activity of 80% cthanolic extract of cumin seeds. The phytochemical tests showed alkaloids, llavonoids, glycosides, tannins, steroids, phenols, saponins, and amino acids were present in the extract whereas resins, triterpine and cyanogenic glycoside were not. Acute toxicity test of the 80% ethanolic extract of cumin seeds showed no toxicity in albino mice, even with maximum permissible dose of 16 g/kg body weight. Antidiarrhoeal activity was evaluated by castor oil-induced diarrhoeal test, cnteropooling test and intestinal transit test on mice. Three doses (3, 6 and 9 g/kg body weight) of tested extracts showed significant antidiarrhoeal effect (% inhibition or defecation) (p<0.0 1) when compared to control. The extracts of 6 g/kg, 9 g/kg and loperamide showed a significant decrease in the onset of defecation (p<0.05) when compared to control. All doses of tested extracts showed anti-diarrhoeal effects comparable to loperamide (6 mg/kg) as seen by a marked decrease in the number or diarrhoeal stools, from 2 1.1 7
SUBJECT HEADINGS:   Antidiarrheals. Plant Extract. Castor Oil

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Vision : Achieving a healthier nation through application of research findings          Mission Statement : To Develop and promote solutions to the major health problems of Myanmar