Myanamr Health Research Registration 2021; 33(1): 44-50.
DOI:
Antihypercholesterolemic Activity of Fruits of Terminalia chebula Retz. (Phanga) in Triton induced Hyperlipidemic Rats
Khine Khine Lwin, Mu Mu Sein Myint, Khin Phyu Phyu, Aye Win Oo, Shwe Sinn Pyone, Phyu Phyu Win, Myint Myint Khine, San San Myint & Nu Nu Win
Myanmar Health Sciences Research Journal
ABSTRACTThis study was conducted to investigate antihypercholesterolemic activity of 70% ethanolic extract from fruits of Terminalia chebula Retz. on triton induced hyperlipidemic rats. Phytochemical tests and acute toxicity test of 70% ethanolic extract of the fruits on albino mice by using OECD 423 guideline were done. A laboratory based experimental animal study with control group was carried out. Thirty albino rats of both sexes for antihypercholesterolemic activity study of fruits of Terminalia chebula were used from 2016 to 2017.
Hyperlipidemia is a disorder of
lipid metabolism manifested by raised plasma
levels of one or more of total cholesterol, low density lipoprotein
cholesterol (LDL), triglyceride or both total cholesterol and triglyceride
(Joint European Society of cardiology guideline, 2012).1
Hyperlipidemia
is a major cause of atherosclerosis and atherosclerosis associated conditions
such as coronary heart disease (CHD), ischaemic cerebrovascular disease and
peripheral vascular diseases.2
Study design
Study
design was laboratory based experi-mental animal study.
Place
of study and study period
The study was in
Pharmacology Research Division, Department of Medical Research and study period
was in 2016-2017.
Plant
materials and preparation for plant extraction
Terminalia
chebula Retz.
mature fruits were collected from Magwe Region and identified by the Botanist from Botany
Department, Yangon University. Terminalia
chebula Retz. fruits excluding seeds were cut into small pieces and air
dried in the shade.
In this study,
hyperlipidemia was induced by intraperitoneal injection of Triton WR 1339. Triton
WR 1339 is one of the many well- known nonionic detergents (surfactant) that
induces the elevation of plasma cholesterol and triglyceride levels by
increasing the hepatic cholesterol synthesis. The sustained hyperlipaemia and
hypercholesterolaemia are induced by interference with the uptake of
plasmalipids by tissues. As a reaction to
the impaired uptake of plasma cholesterol, the rate of endogenous cholesterol
bio-synthesis is rapidly increased in the liver.