Myanmar Health Sciences Research Journal
Original Articles :
Myanamr Health Research Registration 2021; 33(1): 44-50.
DOI:

Antihypercholesterolemic Activity of Fruits of Terminalia chebula Retz. (Phanga) in Triton induced Hyperlipidemic Rats

Khine Khine Lwin, Mu Mu Sein Myint, Khin Phyu Phyu, Aye Win Oo, Shwe Sinn Pyone, Phyu Phyu Win, Myint Myint Khine, San San Myint & Nu Nu Win

Myanmar Health Sciences Research Journal

ABSTRACT

This study was conducted to investigate antihypercholesterolemic activity of 70% ethanolic extract from fruits of Terminalia chebula Retz. on triton induced hyperlipidemic rats. Phytochemical tests and acute toxicity test of 70% ethanolic extract of the fruits on albino mice by using OECD 423 guideline were done. A laboratory based experimental animal study with control group was carried out. Thirty albino rats of both sexes for antihypercholesterolemic activity study of fruits of Terminalia chebula were used from 2016 to 2017. 


RESULT
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INTRODUCTION
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Hyperlipidemia is a disorder of lipid metabolism manifested by raised plasma  levels of one or more of total cholesterol, low density lipoprotein cholesterol (LDL), triglyceride or both total cholesterol and triglyceride (Joint European Society of cardiology guideline, 2012).1

Hyperlipidemia is a major cause of atherosclerosis and atherosclerosis associated conditions such as coronary heart disease (CHD), ischaemic cerebrovascular disease and peripheral vascular diseases.2


SUPPLEMENTARY MATERIAL
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Study design

Study design was laboratory based experi-mental animal study.

Place of study and study period

The study was in Pharmacology Research Division, Department of Medical Research and study period was in 2016-2017.

Plant materials and preparation for plant extraction

Terminalia chebula Retz. mature fruits were collected from Magwe Region and  identified by the Botanist from Botany Department, Yangon University. Terminalia chebula Retz. fruits excluding seeds were cut into small pieces and air dried in the shade. 


DISCUSSION
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In this study, hyperlipidemia was induced by intraperitoneal injection of Triton WR 1339. Triton WR 1339 is one of the many well- known nonionic detergents (surfactant) that induces the elevation of plasma cholesterol and triglyceride levels by increasing the hepatic cholesterol synthesis. The sustained hyperlipaemia and hypercholesterolaemia are induced by interference with the uptake of plasmalipids by tissues. As a reaction to
the impaired uptake of plasma cholesterol, the rate of endogenous cholesterol bio-synthesis is rapidly increased in the liver.


ACKNOWLEDGMENT
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CONFLICT OF INTEREST
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REFERENCES
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